摘要
目的:探究核素肾显像(肾图)在中/高危急性淋巴细胞白血病(ALL)儿童大剂量甲氨蝶呤(MTX)化疗中的应用探析。方法:选取2016年5月至2017年5月某院ALL患儿68例作为研究对象,按病历号尾数单双数随机分为研究组(尾号为双数)和对照组(尾号为单数),每组各34例。研究组患儿采用化疗前行肾图检查的应用治疗,对照组患儿仅采用常规化疗治疗,化疗前未行肾图检查。及时记录两组患儿应用治疗后的治疗效果以及患儿家属满意度并给予对比分析。结果:研究组患儿的治疗效果优于对照组(P<0.05);研究组患儿家属满意度优于对照组(P<0.05)。结论:中/高危ALL患儿化疗前行肾图检查,临床医师可适当把控MTX的使用剂量,优化治疗浓度,降低化疗时产生的不良反应,提高患儿家属满意度。
Objective:To explore the application of renogram in high-dose methotrexate(HD-MTX)chemotherapy for the treatment of children with middle/high risk acute lymphoblastic leukemia(ALL).Methods:A total of 68 cases of middle/high risk ALL children treated in our hospital were selected from May 2016 to May 2017,and randomly divided into the study group(medical record number was even)and the control group(medical record number was odd),with 34 cases in each group.The study group was given renogram examination before chemotherapy,while the control group was treated with only conventional treatment without renogram examination before chemotherapy.Their treatment efficacy and satisfactory degree of family members were timely recorded and compared between the two groups.Results:The treatment efficacy and family members′satisfaction in the study group were better than those of the control group(P<0.05).Conclusion:Renogram examination applied before chemotherapy for children with middle/high risk ALL can help doctors to appropriately manage the dose of methotrexate,and reduce adverse reactions caused by high-dose methotrexate,improve the satisfaction degree of family members.
作者
王广俊
马燕
于宗君
尹莉
WANG Guangjun;MA Yan;YU Zongjun;YIN Li(Department of Pediatrics,Shandong Provincial Third Hosptial,Shandong Ji′nan 250000,China;Department of Endocrinology and Metabolism,Xi'an Children's Hospital,Shaanxi Xi'an 710043,China)
出处
《中国医药导刊》
2019年第10期579-582,共4页
Chinese Journal of Medicinal Guide
关键词
肾图
甲氨蝶呤化疗
白血病患儿
中/高危急性淋巴细胞白血病
治疗
Renogram
Methotrexate chemotherapy
Leukemia children
Middle/high risk acute lymphoblastic leukemia
Treatment
