摘要
目的探讨未足月胎膜早破不同时间应用抗生素治疗对分娩结局的影响。方法应用随机数字表法将我院2017年4月~2018年6月收治的138例未足月胎膜早破患者分为研究1组、研究2组、研究3组,研究1组于胎膜破裂后12h内静脉滴注五水头孢唑林钠,研究2组于胎膜破裂后12~24h静脉滴注五水头孢唑林钠,研究3组于胎膜破裂后超过24h静脉滴注五水头孢唑林钠,均用药3d,比较三组患者入院至分娩时间、宫内感染、产后出血、产褥感染发生情况及新生儿健康状况。结果研究1组入院至分娩时间为(62.98±5.11)h,较研究2组、研究3组的(58.10±4.72)h、(52.33±4.85)h长(P<0.05),宫内感染、产后出血、产褥感染发生率分别为2.17%、4.35%、2.17%,均较研究2组、研究3组低(P<0.05),新生儿Apgar评分为(8.29±0.45)分,研究2组、研究3组的(7.79±0.41)、(7.63±0.39)分高(P<0.05)。结论未足月胎膜早破患者,发病后越早应用抗生素治疗对分娩结局产生的影响越小。
Objective To explore effects of antibiotic treatment on delivery outcomes of preterm premature rupture of membranes in different periods.Methods According to the random number table method,138 patients with preterm premature rupture of membranes who were admitted and treated in our hospital from April 2017 to June 2018 were divided into study one group,study two group and study three group.In study one group,cefazolin sodium pentahydrate was injected by intravenous drip within 12h after rupture of membranes.In study two group,cefazolin sodium pentahydrate was injected by intravenous drip in 12h to 24h after rupture of membranes.In study three group,cefazolin sodium pentahydrate was injected by intravenous drip after rupture of membranes for more than 24h.They all took medicine for three days.The time from admission to delivery,intrauterine infection,postpartum hemorrhage,puerperal infection and neonatal health were compared among the three groups.Results The time from admission to delivery was(62.98±5.11)h in study one group,longer than(58.10±4.72)h in study two group and(52.33±4.85)h in study three group(P<0.05).Incidences of intrauterine infection,postpartum hemorrhage,puerperal infection of study one group were respectively 2.17%,4.35%and 2.17%,lower than those in study two group and study three group(P<0.05).The Apgar score of newborns in study one group was(8.29±0.45)points,higher than(7.79±0.41)points and(7.63±0.39)points in study two group and study three group(P<0.05).Conclusion In patients with preterm premature rupture of membranes,the earlier the antibiotic treatment,the less the effect on delivery outcome.
作者
肖玉霞
XIAO Yuxia(Maoming People's Hospital,Guangdong,Maoming 525000,China)
出处
《中国医药科学》
2019年第20期74-76,共3页
China Medicine And Pharmacy
关键词
未足月胎膜早破
抗生素
五水头孢唑林钠
分娩结局
新生儿Apgar评分
Preterm premature rupture of membranes
Antibiotics
Cefazolin sodium pentahydrate
Delivery outcome
Neonatal Apgar score