摘要
目的分析顺铂与奈达铂同期放化疗结合胎盘多肽注射液治疗晚期复发性鼻咽癌的效果。方法选取2017年1~12月上饶市第五人民医院收治的60例晚期复发性鼻咽癌患者作为研究对象,应用随机数字表法将其分为对照组与观察组,每组各30例。两组患者均接受放射治疗,在此基础上,对照组患者接受顺铂化疗,观察组患者接受奈达铂同步化疗结合胎盘多肽注射液治疗。观察两组患者的治疗总有效率、不良反应发生情况、生存率、生存质量及治疗前后免疫功能。结果两组患者的治疗总有效率比较,差异无统计学意义(P>0.05)。两组患者治疗前的CD4^+、CD8^+、CD4^+/CD8^+比较,差异无统计学意义(P>0.05);对照组患者治疗后的CD4^+、CD4^+/CD8^+均低于治疗前,CD8^+高于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的CD4^+、CD4^+/CD8^+均高于治疗前、对照组,CD8^+低于治疗前、对照组,差异有统计学意义(P<0.05)。观察组患者的恶心/呕吐、口腔黏膜炎发生情况均好于对照组,差异有统计学意义(P<0.05);两组患者的白细胞减少、肝肾功能损伤发生情况比较,差异无统计学意义(P>0.05)。观察组患者的生存质量优于对照组,生存率高于对照组,差异有统计学意义(P<0.05)。结论晚期复发性鼻咽癌患者接受奈达铂同期放化疗结合胎盘多肽注射液治疗有利于增强机体免疫功能,提升患者生存质量及生存率,减少不良反应的发生。
Objective To analyze the effect of concurrent radiotherapy and chemotherapy of Cisplatin and Nedaplatin combined with Placenta Polypeptide Injection in the treatment of advanced recurrent nasopharyngeal cancer.Methods Sixty patients with advanced recurrent nasopharyngeal cancer admitted to the Fifth People′s Hospital of Shangrao City from January to December in 2017 were selected as the study subjects.They were divided into control group and observation group according to the random number table method,30 cases in each group.Both groups received radiotherapy,on this basis,the control group received Cisplatin chemotherapy,and the observation group received concurrent chemotherapy of Nedaplatin combined with Placenta Polypeptide Injection.The total effective rate of treatment,the incidence of adverse reactions,survival rate,quality of life and immune function before and after treatment were observed in the two groups.Results There was no significant difference in the total effective rate of treatment between the two groups(P>0.05).There were no significant differences in CD4^+,CD8^+,CD4^+/CD8^+between the two groups before treatment(P>0.05).The CD4^+and CD4^+/CD8^+in the control group after treatment were lower than those before treatment,the CD8^+was higher than that before treatment,and the differences were statistically significant(P<0.05).The CD4^+and CD4^+/CD8^+in the observation group after treatment were higher than those before treatment and in the control group,CD8^+was lower than that before treatment and in the control group,and the differences were statistically significant(P<0.05).The incidence of nausea/vomiting and oral mucositis in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of leukopenia and liver and kidney function damage between the two groups (P>0.05). The quality of life in the observation group was better than that in the control group, the survival rate was higher than that in the control group, and the differences were statistically significant (P<0.05). Conclusion The concurrent chemotherapy of Nedaplatin combined with Placenta Polypeptide Injection in the treatment of patients with advanced recurrent nasopharyngeal cancer is beneficial to enhance the immune function of the body, improve the quality of life and survival rate, and reduce the incidence of adverse reactions.
作者
邱模军
汪晓梅
肖玉清
QIU Mo-jun;WANG Xiao-mei;XIAO Yu-qing(Department of Tumor Radiotherapy and Chemotherapy,the Fifth People′s Hospital of Shangrao City,Jiangxi Province,Shangrao 334000,China;Department of Oncology,Dexing People′s Hospital,Jiangxi Province,Dexing 334200,China)
出处
《中国当代医药》
2019年第29期58-61,共4页
China Modern Medicine
基金
江西省上饶市科技计划项目(20183CKJ06)
关键词
晚期复发性鼻咽癌
顺铂
奈达铂
胎盘多肽注射液
免疫功能
不良反应
Advanced recurrent nasopharyngeal cancer
Cisplatin
Nedaplatin
Placenta Polypeptide Injection
Immune function
Adverse reactions
