摘要
目的观察慢性阻塞性肺病急性加重期(AECOPD)患者血清总胆红素(TBIL)水平变化及与肺功能参数的关系。方法选择73例AECOPD组患者及35例体检中心健康对照组为研究对象,比较2组血清TBIL的变化;同时观察AECOPD患者治疗前后血清TBIL水平变化,分析血清TBIL和肺功能参数的相关性。结果AECOPD组患者血清TBIL水平低于健康对照组,差异具有统计学意义(P<0.05)。73例AECOPD中21例合并呼吸衰竭。AECOPD合并呼吸衰竭组患者血清TBIL水平低于未合并呼吸衰竭组,差异有统计学意义(P<0.05);GOLD1-2级\GOLD3级、GOLD4级患者血清TBIL水平逐渐下降,差异有统计学意义(P<0.05);AECOPD组患者出院前血清TBIL水平高于入院时血清TBIL水平,差异有统计学意义(P<0.05)。在AECOPD组患者血清TBIL与FEV1和FEV1/FVC呈正相关(r分别为0.911和0.779,P<0.05)。结论血清TBIL水平与COPD急性加重病情相关,AECOPD患者血清TBIL水平下降,且其表达水平与病情严重程度负相关,提示测定血清TBIL有助于AECOPD的病情评估。
Objective To explore the level of serum total bilirubin(TBIL)in chronic obstructive pulmonary disease(COPD)patients in acute exacerbation(AE)stage and its correlation with pulmonary function.Methods A total of 73 AECOPD patients and 35 healthy subjects were enrolled.Their levels of serum TBIL in both groups were determined before and after treatment.The correlation between serum TBIL level and pulmonary function parameters were analyzed.Results AECOPD patients presented remarkably decreased levels of serum TBIL than healthy subjects(P<0.05).There were 21 patients suffering from respiratory failure,among 73 AECOPD patients.Marked decreases were found in the level of serum TBIL in AECOPD patients with respiratory failure,compared with those without respiratory failure(P<0.05).The levels of serum TBIL were gradually decreased in GOLD grades 1-2,3,and 4 patients,where statistical differences were found(P<0.05).AECOPD patients presented significantly higher levels of TBIL on discharge,compared with the levels at admission(P<0.05).The level of TBIL was positively correlated with FEV1 and FEV1/FVC inj AECOPD patients(r=0.911 and 0.779,respectively,P<0.05).Conclusions The level of serum TBIL is associated with aggravated outcomes in COPD patients.The decreased level of serum TBIL in AECOPD patients were negatively correlated with the severity of disease,which suggests that the measurement of serum TBIL is helpful for the evaluation of AECOPD.
作者
赵玲
张毛为
李斯南
张文辉
刘亚南
朱洁晨
罗涛
朱述阳
陈碧
ZHAO Ling;ZHANG Maowei;LI Sinan;ZHANG Wenhui;LIU Yanan;ZHU Jiechen;LUO Tao;ZHU Shuyang;CHEN Bi(Department of Respiratory Medicine,the Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China)
出处
《徐州医科大学学报》
CAS
2019年第10期721-724,共4页
Journal of Xuzhou Medical University
基金
国家自然科学基金青年科学基金(81600044)
江苏省“六大人才高峰”高层次人才项目(WSN-081)
江苏省青年医学人才项目(QNRC2016798)
关键词
慢性阻塞性肺病
急性加重
血清总胆红素
肺功能
chronic obstructive pulmonary disease
acute exacerbation
serum total bilirubin
pulmonary function
