摘要
背景阈下抑郁是指介于健康与抑郁症之间的亚健康状态,因其未满足临床诊断标准,目前多采用非药物治疗。本课题组前期构建喜情绪诱导方案能有效改善个体情绪。从认知层面探索该方案对阈下抑郁个体情绪认知损伤的调节作用,可阐明情绪诱导这类干预方法的作用机制。目的借助事件相关电位技术(ERP)探索阈下抑郁人群的情绪认知功能损伤以及喜情绪诱导方案对其的调节作用。方法 2016年12月-2017年3月,依据ERP试验差异性检验要求招募北京中医药大学本科学生44人。依据流调中心用抑郁量表(CES-D)以及汉密尔顿抑郁量表(HAMD-17)评分分为健康组17人,阈下抑郁组27人;阈下抑郁组采用随机数字表法进一步分为未干预组13人、干预组14人。对所有被试进行ERP试验。干预组在试验前按中医情绪诱导方案进行喜情绪诱导。ERP成分(N2、P3)比较采用两因素重复测量方差分析,以刺激类型(正、中、负)为组内因素,组别(健康组、未干预组、干预组)为组间因素,采用Greenhouse-Geisser修正违反球形假设的重复测量方差分析,Bonferroni校正应用于方差分析后的两两比较。结果与健康组比较,未干预组正性刺激时P3波幅降低,中性刺激时P3潜伏期延长(P<0.05);经过喜情绪诱导后,与未干预组比较,干预组正性刺激时P3波幅升高、P3潜伏期延长,中性刺激时N2波幅降低、P3潜伏期缩短(P<0.05)。结论阈下抑郁个体存在情绪认知功能损伤,喜情绪诱导方案可对其进行有效调节。
Background Subthreshold depression is a sub-health state between health and depression.Because it does not meet the clinical standard,non-drug treatments are more used in practice.The happy emotional induction program developed earlier by our research group can effectively regulate individual emotions,whose mechanism of action may be clarified from the cognitive perspective.Objective The purpose of this study was to explore whether the people with subthreshold depression have emotional cognitive impairment(ECI) and the regulation results of happy emotional induction program for ECI.Methods 44 undergraduate students of Beijing University of Chinese Medicine were recruited from December 2016 to March 2017 in accordance with the criteria of event-related potential(ERP) for testing different cognitive functions,including 17 healthy individuals(control group) and 27 with subthreshold depression 〔subthreshold depression group,was further randomized into induction subgroup(n=14) and non-intervention subgroup(n=13)〕 by the results assessed by Center for Epidemiological Survey,Depression Scale(CES-D) and 17-item Hamilton Depression Rating Scale(HAMD-17).All participants performed ERP experiments without pre-test interventions,except those in the induction group received emotional induction according to the happy emotional induction program.A two-factor repeated measure ANOVA was utilized to examine the latencies and amplitudes of N2 and P3 components,with the group(non-intervention subgroup,induction subgroup and healthy controls) as the between-subject factor,and the emotion(positive,negative,and neutral) as the within-subject factor.The Greenhouse-Geisser correction was used to correct repeated measure ANOVA that violated the sphericity assumption,and the Bonferroni correction was applied to all post-hoc pairwise comparisons.Results Compared with the healthy group,the amplitude of P3 decreased after positive stimulation while the latency of P3 prolonged after neutral stimulation in the non-intervention subgroup(P<0.05).Compared with the non-intervention subgroup,in the induction subgroup,the positive stimulation increased the amplitude of P3,and prolonged the latency of P3,neutral stimulation decreased the amplitude of N2 and shortened the latency of P3(P<0.05).Conclusion There was emotional cognitive impairment in individuals with subthreshold depression.The happy emotional induction program can effectively regulate and improve the cognitive impairment.
作者
张金鹏
李雪
谭曦
杜渐
赵明阳
有明妍
张怡淳子
孔军辉
ZHANG Jinpeng;LI Xue;TAN Xi;DU Jian;ZHAO Mingyang;YOU Mingyan;ZHANG Yichunzi;KONG Junhui(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Beijing Blood Donation Office,Beijing 100088,China;Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Science,Beijing 100700,China;School of Management,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中国全科医学》
CAS
北大核心
2019年第35期4312-4317,共6页
Chinese General Practice
基金
国家自然科学基金面上项目（81273875）
国家自然科学基金青年科学基金项目（81403499）
关键词
抑郁症
阈下抑郁
情绪认知加工
情绪诱导
事件相关电位
Depressive disorder
Subthreshold depression
Emotional cognitive processing
Emotional induction
Event-related potentials
