摘要
研制了一种新型的以阿维菌素为原药,将乳油和泡腾剂结合的剂型--泡腾乳粒剂。使用极少量的溶剂制得乳油,再将其用相应载体和试剂做成泡腾片剂,以达到综合乳油、泡腾剂诸多优点的新剂型。该配方组成为:阿维菌素原药1.8%;乳化剂500#、601#、700#8%;溶剂DMF 5%;泡腾剂柠檬酸、碳酸氢钠40%;崩解剂乳糖、可溶性玉米淀粉25%;黏着剂麦芽糊精5%;填料硫酸铵补足至100%。该制剂分析试验表明,产品各项指标符合可分散片剂、乳粒剂的要求。
In this paper, a new formulation of avermectin effervative emulsion granule was developed, which combines EC with effervescent. The emulsion is prepared by using a small amount of solvent, and then is made into effervescent tablet by using the corresponding carrier and the reagent, so as to reach a new formulation with the advantages of comprehensive emulsifiable concentrate and effervescent agent. The formula comprises the following components in parts by weight: 1.8% of abamectin, 8% of emulsifying agent 500 #, 601 #,700 #, 5% of solvent DMF, 40% of sodium citric acid, baking soda, 25% of disintegrating agent milk sugar,soluble corn, 5% of agglutinant maltodextrin, and the filler ammonia sulfate is made up to 100%. The analysis and test of the preparation show that the indexes of the product meet the requirements of the dispersible tablets and the milk granules.
作者
赵健鹏
李树柏
李波
任西财
ZHAO Jianpeng;LI Shubai;LI Bo;REN Xicai(Qingdao Hansheng Biotechnology Co.,Ltd.,Qingdao 266000,China)
出处
《世界农药》
CAS
2019年第5期48-52,共5页
World Pesticide
关键词
阿维菌素
泡腾剂
乳油
泡腾乳粒剂
avermectin
effervescent
missible oil
effervative emulsion granule
