摘要
目的探讨克氏综合征伴乳腺癌患者的血清促卵泡激素(FSH)、黄体生成素(LH)水平及临床意义。方法依据是否发生乳腺癌将23例克氏综合征患者分为A组和B组,A组为克氏综合征未伴发乳腺癌患者(n=13),B组为克氏综合征伴乳腺癌患者(n=10),另选择染色体核型为46,XY的男性作为C组(n=20)。分析A组和B组克氏综合征患者的染色体核型,比较3组研究对象的血清FSH、LH水平,分析不同雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER2)表达情况的克氏综合征伴乳腺癌患者的血清FSH、LH水平。结果A组和B组克氏综合征患者的染色体核型比较,差异无统计学意义(P﹥0.05)。A组和B组患者的血清FSH、LH水平均高于C组,差异均有统计学意义(P﹤0.05);B组患者的血清FSH水平高于A组,差异有统计学意义(P﹤0.05)。HER2阳性克氏综合征伴乳腺癌患者的血清FSH水平高于HER2阴性患者,差异有统计学意义(P﹤0.05)。结论克氏综合征伴乳腺癌患者的血清FSH水平较高,且血清FSH水平可能与克氏综合征伴乳腺癌患者的HER2表达情况有关。
Objective To explore the serum levels and the clinical significance of follicle-stimulating hormone(FSH)and luteinizing hormone(LH)of breast cancer patients with Klinefelter syndrome.Method Twenty-three patients with Klinefelter syndrome were included in the study and categorized into group A and group B according to whether they had breast cancer or not.Group A comprised patients with Klinefelter syndrome while without breast cancer(n=13),in group B,patients with Klinefelter syndrome and breast cancer were included(n=10),additionally,normal male subjects with karyotype 46,XY were recruited as group C(n=20).The karyotypes of patients with Klinefelter syndrome in group A and group B were analyzed,and the serum FSH and LH levels in the three groups of patients were compared,furthermore,among patients with Klinefelter syndrome and breast cancer,the serum FSH and LH levels in those with different expressions of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor 2(HER2)were compared.Result There was no significant difference in respect to the karyotype between group A and group B patients(P>0.05).The levels of serum FSH and LH in group A and group B were significantly higher than those in group C(P<0.05).The level of serum FSH in group B was higher than that in group A,and the difference was statistically significant(P<0.05).The serum FSH level of HER2-positive patients with Klinefelter syndrome and breast cancer was significantly higher than that of HER2-negative ones,there was statistically significant difference noted(P<0.05).Conclusion The serum FSH level in patients with Klinefelter syndrome and breast cancer is relatively high,and it may be related to HER2 expression in patients with Klinefelter syndrome and breast cancer.
作者
李敏
童芳芳
LI Min;TONG Fangfang(Department of Clinical Laboratory,Qianjiang Central Hospital,Qianjiang 433100,Hubei,China)
出处
《癌症进展》
2019年第21期2552-2555,共4页
Oncology Progress
基金
湖北省卫生和计划生育委员会医药院校科研项目（WJ2016-YZ-16）
关键词
克氏综合征
促卵泡激素
黄体生成素
乳腺癌
Klinefelter syndrome
follicle-stimulating hormone
luteinizing hormone
breast cancer
