摘要
目的分析门冬氨酸鸟氨酸联合纳洛酮在肝性脑病治疗中的应用效果及对患者肝脏功能、生化指标的影响。方法选取2015年1月至2019年1月安徽省濉溪县医院收治的肝性脑病患者60例,随机平分为两组,对照组在常规治疗的基础上使用纳洛酮进行治疗,观察组在对照组治疗的基础上使用门冬氨酸鸟氨酸进行治疗,比较两组患者治疗效果、治疗前后肝脏功能、生化指标水平。结果观察组治疗有效率为93.33%,显著高于对照组(80.00%,P<0.05);观察组治疗后ALT、TBIL和γ-GT水平均明显优于对照组(P<0.05);观察组治疗后血氨水平和β-EP水平均明显低于对照组(P<0.05)。结论门冬氨酸鸟氨酸联合纳洛酮可有效提高肝性脑病治疗效果,对于改善患者的肝脏功能、生化指标水平效果显著,值得推广应用。
Objective To analyze the effect of ornithine aspartate combined with naloxone in the treatment of hepatic encephalopathy and its effect on liver function and biochemical indexes.Methods From January 2015 to January 2019,60 patients with hepatic encephalopathy treated in Suixi County Hospital of Anhui Province were randomly divided into two groups.The control group was treated with naloxone on the basis of routine treatment.The observation group was treated with ornithine aspartate on the basis of treatment in the control group.The therapeutic effect,liver function and biochemical index level before and after treatment were compared between the two groups.Results The effective rate of treatment in the observation group was 93.33%.After treatment,the levels of ALT,TBIL and gamma-GT in the observation group were significantly better than those in the control group(P<0.05),and the levels of blood ammonia andβ-EP in the observation group were significantly lower than those in the control group after treatment(P<0.05).Conclusion Aspartic acid ornithine combined with naloxone can effectively improve the therapeutic effect of hepatic encephalopathy,and it is worth popularizing and applying to improve the liver function and biochemical index level of patients.
作者
薛杰
XUE Jie(Anhui Suixi County Hospital,Huaibei,Anhui 235100,China)
出处
《大医生》
2019年第4期108-109,114,共3页
Doctor
关键词
肝性脑病
纳洛酮
门冬氨酸鸟氨酸
hepatic encephalopathy
naloxone
ornithine aspartate
