摘要
目的 探讨血管球瘤的临床病理特征、诊断与鉴别诊断及治疗与预后。方法 收集2015年1月-2019年2月无锡九院病理科诊断的49例血管球瘤病例,回顾性分析其临床特征、病理学形态和免疫学表型,并结合文献复习进行讨论。结果 典型病理形态为肿瘤细胞圆形、卵圆形,形态较一致,胞质丰富红染、透亮,无明显异型性和核分裂象;肿瘤血管较丰富,瘤细胞围绕血管呈实性巢片状、血管外皮瘤样排列;间质可见黏液变性、玻璃样变性。免疫组化示49例肿瘤细胞SMA、Ⅳ型胶原和vimentin均(+);而CD34、desmin部分病例(+),S-100、calponin、CgA、Syn、EMA、CK、LCA、HMB45、melanA(-)。49例患者术后随访均无复发、转移。结论 血管球瘤是少见的软组织肿瘤,好发于肢端皮下或甲下,确诊依赖于临床特征、组织形态及免疫组化结果相结合,且需要与肌周细胞瘤、血管外皮细胞瘤、皮内痣、基底细胞癌等良恶性病变鉴别。
Objective To investigate the clinicopathological features,diagnosis and differential diagnosis,treatment and prognosis of glomus tumors.Methods A total of 49 cases of glomus tumors diagnosed in the pathology department of Wuxi Nine Hospital from January 2015 to February 2019 were retrospectively analyzed for clinical features,pathological morphology and immunological phenotype.Results The typical pathological morphology was that the tumor cells were round and oval,with uniform morphology.The cytoplasm was rich in red staining and translucent.There was no obvious atypia and mitotic figures.The tumor blood vessels were abundant,and the tumor cells were solid nests around the blood vessels,angioepithelial-like arrangement;mucosal degeneration,vitreous degeneration,interstitial.Immunohistochemistry showed 49 cases of tumor cells SMA,type IV collagen and vimentin(+);while CD34,desmin part(+),S-100,calponin,CgA,Syn,EMA,CK,LCA,HMB45,melanA(-).There were no recurrence or metastasis in 49 patients.Conclusion Hemangioma is a rare soft-tissue tumor that occurs in the subcutaneous or subcutaneous of the extremities.The diagnosis depends on the combination of clinical features,histomorphology and immunohistochemistry,and it needs to be associated with pericytes,angioendothelioma,and skin identification of benign and malignant lesions such as internal hemorrhoids and basal cell carcinoma.
作者
张亚
张鑫
ZHANG Ya;ZHANG Xin(Department of Pathology,Wuxi Nine Hospital,Suzhou University,Wuxi,Jiangsu Province,214062 China;Institute of Hand Surgery,Wuxi Nine Hospital,Suzhou University,Wuxi,Jiangsu Province,214062 China)
出处
《中外医疗》
2019年第29期28-30,共3页
China & Foreign Medical Treatment
关键词
血管球瘤
病理学
鉴别诊断
免疫组化
Glomus tumor
Pathology
Differential diagnosis
Immunohistochemistry
