摘要
目的探讨去整合素金属蛋白酶12(ADAM12)在孕早期唐氏综合征(DS)中的筛查价值。方法选取2018年2月至2019年2月于我院行DS筛查的孕早期孕妇为研究对象,分析其血清中的人绒毛膜促性腺激素(β-hCG)、甲胎蛋白(AFP)和ADAM12水平,探讨其在不同孕周中的水平变化,以及各检验方法的检验灵敏度和特异度。结果不同孕周的孕妇的年龄和体重分布均无显著差异(P均>0.05);随着孕周增加,孕妇的AFP和ADAM12水平逐渐增加,而β-hCG水平逐渐下降,其在各孕周差异具有显著的统计学意义(P均<0.05);唐氏综合征阳性组和正常组的β-hCG、AFP和ADAM12水平均存在显著的统计学差异(P均<0.05);联合β-hCG、AFP和ADAM12检测的AOC曲线下面积显著大于联合β-hCG和AFP检测、以及单独的ADAM12检测(P<0.05)。结论ADAM12在孕早期筛查唐氏综合征中具有较高的应用价值,有待进一步验证后推广使用。
Objective:To investigate the value of integrin metalloproteinase 12(ADAM12)screening in Down′s syndrome(DS)in the early period of pregnancy.Methods:The pregnant women in early pregnancy who were screened by DS in our hospital from February 2018 to February 2019 were selected as subjects,the levels of human chorionic gonadotropin(β-hCG),alpha-fetoprotein(AFP)and ADAM12 in serum were analyzed,and their levels in different gestational weeks were examined,as well as the test sensitivity and specificity of each test method.Results:There was no significant difference in the age and weight distribution of pregnant women with different gestational weeks(P>0.05).With the increase of gestational age,the levels of AFP and ADAM12 in pregnant women increased gradually,while the levels ofβ-hCG gradually decreased,which were in each gestational age.The difference was statistically significant(P<0.05);there was a statistically significant difference in the levels ofβ-hCG,AFP and ADAM12 between the positive group and the normal group(P<0.05);The area under the AOC curve detected by AFP,β-hCG and ADAM12 was significantly larger than that of the combinedβ-hCG and AFP assays,as well as the ADAM12 assay alone(P<0.05).Conclusion:ADAM12 has a high application value in screening Down's syndrome in early pregnancy and needs to be further validated and promoted.
作者
叶丽萍
YE Liping(Department of Gynecology and Health Care,Xiaogang Hospital,Beilun District,Ningbo,Zhejiang 315803)
出处
《中国优生与遗传杂志》
2019年第10期1186-1188,共3页
Chinese Journal of Birth Health & Heredity
