摘要
[目的]观察功能性腹泻患者与健康人群的血浆代谢物差异,探索功能性腹泻潜在标志物,为功能性腹泻的发病机制提供客观依据。[方法]采用液相色谱-质谱联用技术对30例功能性腹泻患者和30例健康志愿者的空腹血浆进行代谢组学分析,运用多元统计分析方法筛选出功能性腹泻的特征差异代谢物。[结果]与健康正常组相比,功能性腹泻组的血清代谢物存在脂质、氨基酸代谢的紊乱。[结论]功能性腹泻患者血清的代谢物与正常人存在较大偏离。功能性腹泻的发生和疾病进展与脂质、氨基酸代谢紊乱有关。
[Objective]To observe the difference of plasma metabolites between patients with functional diarrhea and healthy people,explore the potential markers of functional diarrhea,and provide an objective basis for the pathogenesis of functional diarrhea.[Methods]The fasting plasma of 30 patients with functional diarrhea and 30 healthy volunteers was metabolized by liquid chromatography-mass spectrometry.[Results]Compared with the healthy group,serum metabolites of functional diarrhea group were disordered in lipid and amino acid metabolism.[Conclusion]The metabolites in serum of patients with functional diarrhea were significantly different from those of normal people.The occurrence and progression of functional diarrhea are relative to the disorder of lipid and amino acid metabolism.
作者
王宇
窦丹波
WANG Yu;DOU Dan-bo(Department of Traditional Chinese Medicine,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中国中西医结合消化杂志》
CAS
2019年第11期824-829,共6页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金(No:81804037)
上海市卫计委卫生行业临床研究专项(No:20184Y0047)
