摘要
目的探讨叉头框蛋白Q1(forkhead box Q1,FOXQ1)和上皮钙黏蛋白(epitheia cadherin,E-cadherin)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)中的表达情况及其临床意义。方法应用免疫组化法检测69例口腔鳞癌组织和32例正常口腔黏膜组织中FOXQ1与E-cadherin的表达情况,并分析二者与口腔鳞癌临床病理参数的关系及二者的相关性。结果口腔鳞癌组织中FOXQ1的阳性表达率高于正常口腔黏膜组织(P<0.05),E-cadherin的阳性表达率低于正常口腔黏膜组织(P<0.05);FOXQ1和E-cadherin的表达水平与肿瘤的分化程度及临床分期密切相关,而与患者的年龄、性别、吸烟史及肿瘤直径无明显相关性;口腔鳞癌组织中FOXQ1与E-cadherin的表达呈负相关(r=-0.250,P<0.01)。结论FOXQ1与E-cadherin在口腔鳞癌发展过程中起作用,联合检测二者对口腔鳞癌的早期诊断及预后有一定的临床参考价值。
Objective To explore the expressions and clinical significances of fork-head box Q1(FOXQ1)and epithelial cadherin(E-cadherin)in the Oral squamous cell carcinoma(OSCC).Methods The expression of FOXQ1 and E-cadherin in 69 cases of Oral squamous cell carcinoma(OSCC)and 32 cases of Normal oral mucosa were detected by immunohistochemical method,andχ2 test and Spearman method were used to analyze the relationship between the clinicopathologic parameters of Oral squamous cell carcinoma and the correlation between them.Results Positive expression rate of FOXQ1 was higher than that of Normal oral mucosa(P<0.05),and positive expression rate of E-cadherin was lower than that of Normal oral mucosa(P<0.05).The expression levels of FOXQ1 and E-cadherin were closely correlated with the degree of tumor differentiation and clinical stage,but not significantly correlated with the age,sex,smoking history and tumor size of patients.There was a negative correlation between FOXQ1 and E-cadherin expression in Oral squamous cell carcinoma(r=-0.250,P<0.01).Conclusion The high expression High expression level of FOXQ1 and the low expression High expression level of E-cadherin play a role in the occurrence,development and metastasis of Oral squamous cell carcinoma,and the combined detection of FOXQ1 and E-cadherin has a certain clinical reference value for the early diagnosis and prognosis of Oral squamous cell carcinoma.
作者
闫冰
朴松林
杨海燕
元冬梅
沈禹辰
李吉辰
Yan Bing;Piao Songlin;Yang Haiyan(Department of Oral and Maxillofacial Surgery,The Affiliated Hospital of Stomatology,Harbin Medical University,Heilongjiang 150000,China)
出处
《医学研究杂志》
2019年第10期104-107,112,共5页
Journal of Medical Research
基金
黑龙江省教育厅科学技术研究指导项目(10553042)
黑龙江省教育厅科学技术研究基金资助项目(面上项目)(12541273)
