摘要
目的观察金乌骨通胶囊辅助踝关节清理术治疗踝关节骨性关节炎的临床效果及对关节功能的影响。方法选取我院2016年10月--2018年10月收治的踝关节骨性关节炎患者68例,按用药分为观察组和对照组,每组34例。对照组给予布洛芬片,观察组给予金乌骨通胶囊。比较2组临床疗效、治疗前后美国足踝外科协会(AOFAS)踝与后足评分、McGuire踝关节评分、Mazur踝关节评分、血清超氧化物歧化酶(SOD)、一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、IL-6及血清超敏C反应蛋白(hs-CRP)水平变化。结果观察组治疗总有效率高于对照组(P<0.05)。2组AOFAS评分、McGuire评分、Mazur评分高于治疗前,且观察组高于对照组(P<0.05)。2组治疗后血清SOD高于治疗前,且观察组高于对照组(P<0.05);2组NO、TNF-α、hs-CRP、IL-1β和IL-6水平低于治疗前,且观察组低于对照组(P<0.05)。结论金乌骨通胶囊辅助踝关节清理术治疗踝关节骨性关节炎,疗效显著,能够帮助患者更快的恢复关节功能。
Objective To observe curative effectiveness of ankle joint debridement assisted by Jinwu Gutong Capsule in treatment of patients with ankle osteoarthritis and its effect on joint function.Methods A total of 68 patients with ankle osteoarthritis admitted during October 2016 and October 2018 were divided into observation group and control group(n=34 in each group).Control group was given Ibuprofen Tablets,while observation group was given Jinwu Gutong Capsule.In two groups,clinical effectiveness was compared;scores of American Orthopaedic Foot and Ankle Society(AOFAS),McGuire ankle joint and Mazur ankle joint,changes of serum superoxide dismutase(SOD),nitric oxide(NO),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)and serum high-sensitivity C-reactive protein(hs-CRP)levels before and after treatment were compared.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05).AOFAS,McGuire and Mazur scores after treatment were significantly higher than those before treatment in two groups,and the scores in observation group were significantly higher than those in control group(P<0.05).Levels of serum SOD after treatment were significantly higher than those before treatment in two groups,and the level in observation group was significantly higher than that in control group(P<0.05).Levels of NO,TNF-α,hs-CRP,IL-1βand IL-6 were significantly lower than those before treatment in two groups,and the levels in observation group were significantly lower than those in control group(P<0.05).Conclusion Ankle joint debridement assisted by Jinwu Gutong Capsule may achieve good effectiveness in treatment of patients with ankle osteoarthritis,and it can help patients recover joint function more quickly.
作者
付婷
何佳
柴惠斌
史达
赵宏谋
FU Ting;HE Jia;CHAI Hui-bin;SHI Da;ZHAO Hong-mou(Department of TCM Osteoarthrosis,Honghui Hospital Affiliated to Xi'an Jiaotong University,Xi'an 710054,China;Department of Ankle and Foot Surgery,Honghui Hospital Affiliated to Xi'an Jiaotong University,Xi'an 710054,China)
出处
《解放军医药杂志》
CAS
2019年第11期97-100,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
国家自然科学基金项目(81301604)
