摘要
目的分析甲泼尼龙序贯治疗哮喘重度急性发作的疗效和安全性。方法选取2017年11月~2018年11月期间我院收治哮喘重度急性发作患者100例,随机分为对照组47例和试验组53例。给予对照组氢化可的松治疗,给予试验组患者甲泼尼龙序贯治疗。比较分析两组患者肺功能FEV1值、FEV1占预计值%、FVC值、EOS计数、血清总IgE、血气指标PaO2、PaCO2。结果治疗后试验组患者FEV1、FEV1占预计值%明显降低,FVC值明显上升,与对照组比较差异有统计学意义(P<0.05),试验组患者PaCO2指标显著低于对照组,PaO2显著高于对照组(P<0.05)。治疗前两组患者血清总IgE和EOS计数无明显差异,治疗后试验组患者血清总IgE和EOS计数明显低于对照组,差异有统计学意义(P<0.05)。结论针对于哮喘重度急性发作患者尽快采用甲泼尼龙序贯治疗能够显著改善治疗效果,值得临床中推广使用。
Objective To analyze the efficacy and safety of methylprednisolone in the sequential treatment of severe acute asthma attack.Methods One hundred patients with severe acute asthma attack admitted to our hospital from November 2017 to November 2018 were selected and randomly divided into the control group(n=47)and the experimental group(n=53).The control group was given hydrocortisone treatment and the experimental group was given methylprednisolone sequential treatment.The lung function FEV1 value,FEV1%,FVC value,EOS count,Serum total IgE and blood gas indices PaO2 and PaCO2 were compared and analyzed.Results After treatment,the FEV1 and FEV1%in the experimental group decreased significantly and the FVC increased,which were statistically different from those in the control group(P<0.05).The PaCO2 index in the experimental group was significantly lower than that in the control group,and the PaO2 in the experimental group was significantly higher than that in the control group(P<0.05).Before treatment,the serum total IgE and EOS counts between the two groups were not significantly different,but after treatment,the serum total IgE and EOS counts in the experimental group were significantly lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Early application of methylprednisolone sequential treatment in the patients with severe acute asthma attack has significant treatment effects,which is worthy of clinical promotion and application.
作者
王芮琦
沈波
WANG Ruiqi;SHEN Bo(Department of Respiratory Medicine,Huanggu Branch of Northeast International Hospital,Shenyang 110000,China)
出处
《中国现代医生》
2019年第29期94-96,共3页
China Modern Doctor
关键词
甲泼尼龙
序贯治疗
哮喘重度急性发作
Methylprednisolone
Sequential treatment
Severe acute asthma attack
