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鼻内滴注右美托咪定在幼儿外周静脉穿刺和影像学检查中的镇静效果

Sedative effect of intranasal drip of dexmedetomidine on peripheral venipuncture and imaging examination in children
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摘要 目的探讨鼻内滴注右美托咪定在幼儿外周静脉穿刺和影像学检查中的镇静效果.方法选取于我院行CT/MRI检查需镇静治疗的60例患儿作为研究对象,采用随机数字表法将其分为C组和D组,各30例.C组给予水合氯醛治疗,D组给予鼻内滴注右美托咪定治疗.比较两组患儿的镇静效果.结果D组患儿的镇静时间短于C组,镇静失败率及GDRS评分均低于C组(P<0.05).D组患儿家长和检查医师的满意度显著高于C组(P<0.05).D组患儿的苏醒期躁动和恶心、呕吐发生率均低于C组(P<0.05).结论鼻内滴注右美托咪定可减轻患儿外周静脉穿刺时疼痛,为影像学检查提供良好的镇静效果. Objective To explore the sedative effect of intranasal drip of dexmedetomidine on peripheral venipuncture and imaging examination in children. Methods Sixty children who need sedation treatment in our hospital for CT/MRI examination were selected as the study objects, and they were divided into group C and group D by random number table method, with 30 cases in each group. The group C was treated with chloral hydrate, and the group D was treated with intranasal drip of dexmedetomidine. The sedative effects of the two groups were compared. Results The sedation time in the group D was shorter than that in the group C, and the failure rate of sedation and GDRS score were lower than those in the group C(P <0.05). The satisfaction of parents and examiners in the group D were significantly higher than those in the group C(P<0.05). The incidences of restlessness in waking period, nausea and vomiting in the group D were lower than those in the group C(P <0.05). Conclusion Intranasal drip of dexmedetomidine can alleviate the pain of peripheral venipuncture and provide good sedative effect for imaging examination.
作者 冯毅 马亚飞 关静 刘丹丹 贾玉涛 FENG Yi;MA Ya-fei;GUAN Jing;LIU Dan-dan;JIA Yu-tao(Clinical Medicine College of Henan University of Science and Technology/the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)
出处 《临床医学研究与实践》 2019年第33期89-90,共2页 Clinical Research and Practice
关键词 右美托咪定 静脉穿刺 影像学检查 dexmedetomidine venipuncture imaging examination
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  • 1Cortellazzi P, Lamperti M, Minati L, et al. Sedation of neu- rologically impaired children undergoing MRI: a sequential approach. Paediatr Anaesth, 2007,17 (7) : 630-636.
  • 2Low E, ODriscoll M, MacEneaney P, et al. Sedation with oral chloral hydrate in children undergoing MRI scanning. Ir Med J, 2008,101 (3) : 80-82.
  • 3Czapp M,Bankstahl JP,ZibelI G, et al. Brain penetration and anticonvulsant efficacy of intranasal phenobarbital in rats. Epilepsia, 2008,49 (7) : 1142-1150.
  • 4Yuen VM, Hui TW, Irwin MG, et al. A comparison of in- tranasal dexmedetomidine and oral midazoam for premediea- tion in pediatric anesthesia: a double-blinded randomized con- trolled trial. Anesth Analg, 2008,106 (8) : 1715-1721.
  • 5Ghati AM, Mahfouz AK, A1-Bahrani M. Preanesthetic medica- tion in children: A comparison of intranasal dexmedetomidine versus oral midazolam. Saudi J Anaesth, 2011,5(4) :387-391.
  • 6Yuen VM, Irwin MG, Hui TW, et al. A double-blind,crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine. Anesth Analg, 2007, 105 (2) : 374-380.
  • 7Yuen VM, Hui TW, Irwin MG, et al. Optimal timing for the administration of intranasa[ dexmedetomidine for premedica- tion in children. Anaesthesia, 2010,65 (9) : 922-929.
  • 8Iirola T, Vilo S, Manner T, et al. Bioavailability of dexme- detomidine after intranasal administration. Eur J Clin Phar- maeol, 2011,67(8) : 825-831.
  • 9Krauss B, Green SM. Procedural sedation and analgesia in children. Lancet, 2006,367 (9512): 766-780.
  • 10Wermeling DP, Miller JL, Archer SM, et al. Bioavailability and pharmacokinetics of lorazepam after intranasal, intrave- nous, and intramuscular administration. J Clin Pharmacol, 2001,41(11) : 1225-1231.

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