摘要
目的探讨丁苯酞氯化钠注射液联合超早期康复训练治疗急性脑梗死的效果及安全性。方法选择收治的107例急性脑梗死患者,随机分为观察组和对照组,其中观察组55例,对照组52例。在常规治疗的同时,对照组给予超早期康复训练治疗,观察组给予丁苯酞氯化钠注射液联合超早期康复训练治疗。比较两组治疗前后Fugl-Meyer(FMA)评分、Barthel指数、NIHSS评分、神经功能缺损评分及血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)含量。同时记录两组治疗期间不良反应发生情况。结果观察组患者的临床总有效率明显高于对照组(P<0.05)。与治疗前相比,两组治疗后FMA评分及Barthel指数升高,NIHSS评分及神经功能缺损评分降低(P<0.05),且观察组治疗后FMA及Barthel指数高于对照组,NIHSS评分及神经功能缺损度评分低于对照组(P<0.05)。两组患者治疗后TNF-α水平降低,IL-10水平升高(P<0.05),且观察组治疗后TNF-α水平低于对照组,IL-10水平高于对照组(P<0.05)。两组均无明显不良反应发生。结论丁苯酞氯化钠注射液联合超早期康复训练治疗急性脑梗死的临床疗效显著,能够有效地改善急性脑梗死患者的神经缺损程度,改善患者日常行为能力,且安全性较好,值得在临床上推广应用。
Objective To investigate the efficacy and safety of butylphthalide injection combined with hyper-early rehabilitation training on the treatment of acute cerebral infarction.Methods A total of 107 patients with acute cerebral infarction admitted to our hospital were randomly divided into research group(n=55)and control group(n=52).At the same time of routine treatment,the control group was given hyper-early rehabilitation training treatment;meanwhile,the research group was given with butylphthalide injection combined with hyper-early rehabilitation training treatment.FMA,Barthel index,NIHSS score,nerve function defect degree score and plasma TNF-alpha and IL-10 levels were compared before and after treatment.Adverse reactions during treatment in both groups were also recorded.Results The total clinical effective rate of the research group was significantly higher than that of the control group(P<0.05).Compared with the control group,the FMA and Barthel indexes of the two groups were significantly increased after treatment,while the NIHSS scores and the degree of clinical neurological defects were significantly reduced(P<0.05).The FMA and Barthel indexes of the research group were significantly higher than those of the control group,and the degree of clinical neurological defects of the NIHSS was significantly lower than that of the control group(P<0.05).After treatment,TNF-alpha level significantly decreased and IL-10 level significantly increased in the two groups(P<0.05).TNF-alpha level was significantly lower in the research group than that in the control group,while IL-10 level was significantly higher than that in the control group(P<0.05).There were no obvious adverse reactions reported in both groups.Conclusion Butylphthalide injection combined with hyper-early rehabilitation training for the treatment of acute cerebral infarction has a significant clinical effect,which can effectively improve the degree of nerve defects in patients with acute cerebral infarction,improve the ability of patients with daily behavior and have a good safety.
作者
张艳霞
刘玉清
马朝阳
孙平鸽
ZHANG Yan-xia;LIU Yu-qing;MA Chao-yang;SUN Ping-ge(Department of General Practice,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450006,Henan,China)
出处
《广东医学》
CAS
2019年第20期2872-2875,共4页
Guangdong Medical Journal
基金
河南省医学科技攻关计划项目(编号:162102310011)
关键词
急性脑梗死
丁苯酞氯化钠注射液
早期康复训练
神经功能缺损
疗效
acute cerebral infarction
butylphthalide injection
early rehabilitation training
neurological impairment
the curative effect
