摘要
目的:评估术前ALBI评分对符合米兰标准的肝癌患者术后并发症的预测价值。方法:纳入2009年至2016年间接受开放肝癌切除术的400例符合米兰标准的肝癌患者。采用受试者工作特征(ROC)曲线分析确定ALBI的最佳截断值。进行单因素和多因素分析以确定术后并发症发生的相关危险因素。研究术前ALBI评分与临床病理参数的相关性。结果:预测术后并发症ALBI评分的最佳截断值-2.62。多因素分析提示ALBI评分是术后并发症的独立预后因素。ALBI评分>-2.62的肝癌患者术中出血量、住院时间和术后并发症发生率也显著高于对照组(ALBI≤-2.62)。结论:术前ALBI评分是预测符合米兰标准的肝癌术后并发症的有效指标。在日常临床实践中ALBI评分可作为肝储备分层的生物标志物。
Objective:To investigate the ability of preoperative ALBI score to predict short-term outcomes following liver resection for HCC within the Milan Criteria.Methods:ALBI score was evaluated in 400 patients undergoing liver resection for HCC within the Milan Criteria.The receiver operating characteristic curve analysis was conducted to determine the cutoff value of the ALBI score in predicting postoperative morbidity.Univariate and multivariate analysis were performed to identify the risk factors for postoperative outcomes.The correlation of the preoperative ALBI score value with clinicopathological parameters was also examined.Results:We found that the optimal cutoff value of the ALBI score was set at-2.62 for postoperative complications.ALBI score was an independent risk factor for overall complications by univariate and multivariate analyses.HCC patients with elevated ALBI score(>-2.62) had a more intraoperative bleeding,longer hospitalization and significantly higher postoperative complication rate compared with those with ALBI score(≤-2.62).Conclusion:Preoperative ALBI score is a useful biochemical marker to predict postoperative outcomes in HCC patients within the Milan Criteria.The ALBI score should be assessed routinely for HCC patients within the Milan Criteria.
作者
程继文
杨薇粒
赵璞
董健
Li Xiaofeng;Zou Xueting;Wang Yuanyuan;Zhang Guanjun;Liu Xi(Department of Pathology,First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China;Department of Pathology,Northwest Women and Children's Hospital,Shaanxi Xi'an 710061,China.)
出处
《现代肿瘤医学》
CAS
2019年第23期4246-4250,共5页
Journal of Modern Oncology
基金
陕西省创新人才推进计划-青年科技新星项目(编号:2018KJXX-050)
西安交通大学自由探索与创新项目[编号:XJJ2018126,YJ(ZD)201704]
关键词
肝癌
ALBI评分
肝切除术
并发症
hepatocellular carcinoma
ALBI score
hepatectomy
complication
