摘要
目的探讨腰痛宁胶囊联合塞来昔布胶囊治疗腰椎间盘突出症的临床疗效。方法选取2017年2月-2019年1月在盐城市第三人民医院就诊的92例腰椎间盘突出症患者为研究对象,按照随机数字表法分为对照组和治疗组,每组各46例。对照组口服塞来昔布胶囊,0.2 g/次,1次/d。治疗组在对照组基础上口服腰痛宁胶囊,1.2 g/次,1次/d。两组患者均连续治疗3个月。观察两组的临床疗效,比较两组的腰椎功能、细胞因子水平、腰椎活动度。结果治疗后,对照组和治疗组的总有效率分别为78.26%、93.48%,两组比较差异有统计学意义(P<0.05)。治疗后,两组主观症状评分、临床体征评分、日常活动受限度评分、日本骨科协会评估治疗(JOA)总评分均明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组腰椎功能评分明显高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组5羟色胺(5-HT)、前列腺素E2(PGE2)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组的细胞因子水平比对照组低,差异有统计学意义(P<0.05)。治疗后,两组腰椎的前屈、后伸活动度明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组腰椎的前屈、后伸活动度比对照组高,差异有统计学意义(P<0.05)。结论腰痛宁胶囊联合塞来昔布胶囊治疗腰椎间盘突出症具有较好的临床疗效,可改善患者的腰椎功能,降低血清因子水平,具有一定的临床推广应用价值。
Objective To explore the effect of Yaotongning Capsules combined with Celecoxib Capsules in treatment of lumbar disc herniation. Methods Patients(92 cases) with lumbar disc herniation in Yancheng Third People’s Hospital from February 2017 to January 2019 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were po administered with Celecoxib Capsules, 0.2 g/time, once daily. Patients in the treatment group were po administered with Yaotongning Capsules on the basis of the control group, 1.2 g/time, once daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and lumbar spine function, cytokine levels, and lumbar mobility in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.26% and 93.48%, respectively, and there was difference between two groups(P < 0.05). After treatment, subjective symptom score, clinical sign score, limited daily activity score, and JOA Total Score in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of 5-HT, PGE2, IL-1β, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the cytokine levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the range of flexion and extension of lumbar spine in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the lumbar mobility in the treatment group were significantly higher than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Yaotongning Capsules combined with Celecoxib Capsules has clinical curative effect in treatment of lumbar disc herniation, can improve the lumbar spine function, and reduce the level of serum factors, which has a certain clinical application value.
作者
车玥琛
张哲
车月玫
CHE Yue-chen;ZHANG Zhe;CHE Yue-mei(Department of Orthopedics,Yancheng Third People’s Hospital,Yancheng 224001,China;Department of Obstetrics and Gynecology,Air Force Hospital of Eastern War Zone,Nanjing 210000,China)
出处
《现代药物与临床》
CAS
2019年第10期3123-3126,共4页
Drugs & Clinic
