摘要
目的探讨白细胞介素-6(IL-6)基因-597G/A多态与遵义人群混合型高脂血症的相关性。方法2014年3-8月采用聚合酶链反应产物直接测序分析100例混合型高脂血症患者(混合型高脂血症组)和112例健康者(健康组)IL-6基因-597G/A多态性。结果健康组研究对象IL-6基因-597G/A位点检测到GA基因型杂合子个体1例,混合型高脂血症组患者中没有检测到GA基因型杂合子个体;2组研究对象中均未检测到AA突变基因型个体。结论遵义人群IL-6基因-597G/A位点多态性很低。
Objective To explore the correlation between interleukin-6(IL-6)gene-597G/A polymorphism and mixed hyperlipidemia in Zunyi population.Methods From March to August 2014,polymerase chain reaction products were directly sequenced to analyze the polymorphism of IL-6 gene-597G/A 100 patients combined hyperlipidemia patients(mixed hyperlipidemia group)and 112 healthy patients(healthy group).Results One heterozygote of GA genotype was detected at the locus of IL-6 gene-597 G/A in healthy group,and no heterozygote of GA genotype was detected in mixed hyperlipidemia group,and AA mutation genotype was detected in both groups.Conclusion The polymorphism of IL-6 gene-597G/A is very low in Zunyi population.
作者
梁玉佳
杨月
赵敏
郑威龙
赵雁
张志敏
LIANG Yujia;YANG Yue;ZHAO Min;ZHENG Weilong;ZHAO Yan;ZHANG Zhimin(Zunyi Medical University,Zunyi,Guizhou 563099,China)
出处
《现代医药卫生》
2019年第22期3419-3421,共3页
Journal of Modern Medicine & Health
基金
贵州省科技厅医学科研项目(黔科合J字LKZ〔2012〕39号)
国家级大学生创新创业训练计划项目(201710661010)
贵州省大学生创新创业训练计划项目(201710661010)
遵义医学院大学生创新创业训练计划项目(遵医20163708、遵医科院20162316)
