摘要
目的:探究支气管镜下冷冻治疗支气管结核(endobronchial tuberculosis,EBTB)的临床应用。方法:研究对象为本院2018年1月-2019年1月收治的85例EBTB患者。按治疗方案分A组(n=40,常规抗结核治疗)与B组(n=45,常规抗结核联合冷冻治疗)。记录B组冷冻治疗次数及并发症发生率。比较两组临床疗效、症状及免疫功能情况。结果:B组冷冻次数为2~6次,平均(3.97±0.52)次;治疗期间未见出血、穿孔等并发症发生,均顺利完成治疗。B组治疗总有效率明显高于A组(P<0.05)。治疗后两组气道直径、气促指数、第一秒最大呼气量(FEV1)均明显优于治疗前,且B组气道直径、气促指数及FEV1均优于A组(P<0.05)。治疗后两组CD3^+、CD4^+、CD4^+/CD8^+均高于治疗前,CD8^+低于治疗前,B组CD3^+、CD4^+、CD4^+/CD8^+均明显高于A组,CD8^+明显低于A组(P<0.05)。结论:支气管镜下冷冻治疗EBTB效果明显、安全性良好,可明显改善症状及免疫功能,值得临床推广。
Objective: To explore clinical application of bronchoscopic cryotherapy in treatment of endobronchial tuberculosis(EBTB). Method: The study subjects were 85 EBTB patients admitted to the hospital from January 2018 to January 2019. According to different treatment plans, they were divided into group A(n=40, routine treatment) and group B(n=30, routine treatment combined with cryotherapy). The number of cryotherapy and incidence of complications during treatment in group B were recorded. The clinical curative effect, symptoms and immune function were compared between the two groups. Result: The number of cryotherapy in group B was 2-6 times, with an average of(3.97±0.52) times. There were no complications such as hemorrhage and perforation during treatment. The treatment was successfully completed for group B. The total effective rate of group B was significantly higher than that of group A(P<0.05). After treatment, airway diameter, polypnea index and forced expiratory volume in 1 second(FEV1) in both groups were significantly better those before treatment, and airway diameter, polypnea index and FEV1 in the group B were better than those in the group A(P<0.05). After treatment, CD3^+, CD4^+ and CD4^+/CD8^+ in both groups were higher than those before treatment, while CD8^+ was lower than that before treatment, and CD3^+, CD4^+ and CD4^+/CD8^+ in group B were significantly higher than those in group A, while CD8^+ was significantly lower than that in group A(P<0.05). Conclusion: The effect of bronchoscopic cryotherapy on EBTB is obvious, with good safety, it can obviously improve the symptoms and immune function, and is worthy of clinical promotion.
作者
徐艳
罗欣
XU Yan;LUO Xin(People’s Hospital of Yichun City,Yichun 336000,China)
出处
《中国医学创新》
CAS
2019年第32期119-122,共4页
Medical Innovation of China
基金
宜春市科技局社会发展计划项目（2019132）
关键词
支气管镜
冷冻治疗
支气管结核
Bronchoscope
Cryotherapy
Endobronchial tuberculosis
