摘要
目的观察益气养阴方联合吲哚美辛肠溶片治疗晚期肿瘤癌性发热(气阴双虚证)的有效性,以期为临床提供有效方法。方法将94例晚期癌性发热(气阴双虚证)肿瘤患者根据随机数字表法分为治疗组与对照组各47例,对照组给予吲哚美辛肠溶片口服12.5 mg,每日3次,治疗组在对照组基础上给予益气养阴方口服,两组均治疗7 d。观察治疗前后发热缓解率,生活质量评分(KPS),焦虑、抑郁评分,中医证候量表评分,血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)及环氧化酶-2(COX-2)]不良反应。结果两组治疗后缓解率比较,治疗组明显高于对照组(P<0.05)。两组治疗后在中医症状量表评分、KPS评分、SAS评分、SDS评分,两组对比治疗组优于对照组(P<0.05)。两组治疗前后TNF-α、IL-1β及COX-2水平均明显改善,且治疗组改善更显著(P<0.05)。两组服药后未出现不良反应。结论益气养阴方联合吲哚美辛肠溶片治疗晚期肿瘤癌性发热(气阴双虚证)有良好效果。
Objective:To observe the efficacy of Yiqi Yangyin Decoction combined with Indomethacin Entericcoated Tablets on advanced cancer fever,and to provide an effective method for clinical treatment.Methods:94 patients were randomly divided into the treatment group and the control group,47 cases in each.The control group was given Indomethacin Enteric-coated Tablets 12.5 mg 3/day orally.The treatment group was given Yiqi Yangyin Decoctiom orally on that basis.Both groups were treated for 7 days.The fever relief rate,KPS score,anxiety and depression score before and after treatment were observed,as well as syndrome scale score and serum inflammatory factors(TNF-α,IL-1βand COX-2),adverse reactions.Results:The remission rate in the treatment group was higher obviously than that in the control group(P<0.05).After treatment,the scores of TCM symptom scale,KPS,SAS and SDS in the treatment group were better than those in the control group(P<0.05).The levels of serum inflammatory factors,TNF-α,IL-1βand COX-2 were significantly different before and after treatment(P<0.05).There were no adverse reactions after treatment in the two groups.Conclusion:Yiqi Yangyin Decoction combined with Indomethacin Enteric-coated Tablets has a good effect on advanced cancer fever(deficiency of both Qi and Yin),worthy of clinical application and promotion.
作者
吴昭利
杨得振
祝云鹤
李仁廷
Wu Zhaoli;Yang Dezhen;Zhu Yunhe(Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Shaanxi,Xianyang 710038,China)
出处
《中国中医急症》
2019年第11期1957-1960,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
陕西省卫计委课题(2018E018)
关键词
癌性发热
益气养阴方
吲哚美辛肠溶片
临床观察
Cancerous fever
Yiqi Yangyin Decoctiom
Indomethacin Enteric-coated Tablets
Clinical observation
