摘要
背景:青少年特发性脊柱侧凸导致脊柱结构和应力发生改变,腰椎在脊柱中承受的载荷最大,骨盆也起着传导重力的作用,故青少年特发性脊柱侧凸腰主弯患者腰椎骨盆的生物力学分析尤为重要。目的:建立青少年特发性脊柱侧凸腰主弯腰椎-骨盆三维数字化模型并进行有限元分析。方法:根据1例13岁女性特发性脊柱侧凸腰主弯患者的腰椎-骨盆CT薄层数据,应用Mimics 15.0软件重建三维数字化模型,以Pro/E 5.0软件建立初步几何模型并导入Hypermesh 13.0进行网格划分,最终通过Abaqus 6.14软件对该模型进行有限元分析。分析有限元模型在6种载荷条件下的位移、应力变化及该模型各椎体及椎间盘的应力变化。患者家属对试验方案知情同意,且得到医院伦理委员会批准。结果与结论:①建立了青少年特发性脊柱侧凸腰主弯患者的腰椎-骨盆的三维有限元模型;②模型在6种载荷条件下,L 1椎体上部在左、右侧屈时位移变化最大,骶骨下端在前屈时位移最大;③椎间盘右缘在右侧屈运动条件下所受应力最大;前屈位时,腰椎间盘所受应力为前缘最大,左缘所受应力最小;后伸位时后缘所受应力最大,而右缘所受应力最小;侧屈位及旋转位时,右缘所受应力最大,前缘所受应力最小;④L 5在6种运动中应力均最大,其中应力集中于上下关节突及椎弓根,尤其以右侧最为集中;⑤提示青少年特发性脊柱侧凸不同载荷会引起椎体或椎间盘不同位置受力及位移有相应变化,研究结果对脊柱侧凸的治疗和预防具有重要意义。
BACKGROUND: Adolescent idiopathic scoliosis causes changes in the structure and stress of the spine. The lumbar spine bears the greatest load in the spine, and the pelvis also plays the role of transmitting gravity. Therefore, the biomechanical analysis of the lumbar spine and pelvis in adolescent idiopathic scoliosis with lumbar major curve is particularly important. OBJECTIVE: To establish the three-dimensional digital model of lumbar spine-pelvis in adolescent idiopathic scoliosis and undergo finite element analysis. METHODS: The CT microscopic data of the lumbar spine-pelvis in a 13-year-old idiopathic scoliosis volunteer were used to reconstruct the three-dimensional digital model using mimics 15.0 software. The preliminary geometric model was established by Pro/E 5.0 software and imported into Hypermesh 13.0 for mesh generation. The model was finally subjected to finite element analysis by Abaqus 6.14 software. The displacement, stress changes of the model under six load conditions, and the stress changes of each vertebra and intervertebral disc were analyzed. The study was approved by the ethical committee of the hospital, and the patient family member signed the informed consents. RESULTS AND CONCLUSION: (1) A three-dimensional finite element model of the lumbar spine-pelvis in adolescent idiopathic scoliosis was established. (2) Under the six kinds of loading conditions, the displacement of the upper part of the L1 was the largest in the left and right flexion, and the displacement of the lower end of the tibia was the largest in the flexion. (3) The right margin of the intervertebral disc had highest stress under right flexion. Under anterior flexion position, the lumbar intervertebral disc was subjected to the highest stress on the anterior margin and the stress on the left margin was the least stressed. The posterior margin had the highest stress under posterior extension. The edge was subjected to the least stress;when the lateral flexion and the rotational position, the right edge was subjected to the most stress, and the leading edge was subjected to the least stress. (4) L5 had the largest stress in all six movements, and the stress was concentrated on the upper and lower articular processes and pedicles, especially on the right side. (5) In summary, for adolescent idiopathic scoliosis, different loads may cause different stresses and displacement values of the vertebral body or intervertebral disc under different positions. These results are of great significance for the treatment and prevention of scoliosis.
作者
张聪
赵岩
杜小宇
杜欣瑞
庞廷娟
付怡凝
张浩
张步洲
李筱贺
王利东
Zhang Cong;Zhao Yan;Du Xiaoyu;Du Xinrui;Pang Tingjuan;Fu Yining;Zhang Hao;Zhang Buzhou;Li Xiaohe;Wang Lidong(Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Department of Orthopedics,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Laboratory of Anatomy,School of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Inner Mongolia International Mongolia Hospital,Hohhot 010110,Inner Mongolia Autonomous Region,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第8期1155-1161,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金（81460330），项目负责人：李筱贺
内蒙古教育厅青年科技英才项目（njyt-15-b05），项目负责人：李筱贺
内蒙自治区科技计划项目（2016），项目负责人：李筱贺
内蒙古自治区科技创新引导项目（2017），项目负责人：李筱贺
内蒙古自治区自然科学基金（2016ms08131），项目负责人：李筱贺
内蒙古人社厅归国留学人员基金（201620），项目负责人：李筱贺~~
关键词
青少年
特发性脊柱侧凸
腰主弯
腰椎
骨盆
有限元分析
生物力学
国家自然科学基金
adolescent
idiopathic scoliosis
main bend
lumbar vertebrae
pelvis
finite element analysis
biomechanics
the National Natural Science Foundation of China
