摘要
目的:探讨玻璃体腔注射康柏西普联合Ahmed青光眼引流阀植入和视网膜光凝对新生血管性青光眼(NVG)的治疗效果。方法:回顾性研究。分析2017年6月至2018年6月于空军986医院眼科就诊的NVG患者16例(17眼),先行玻璃体腔注射康柏西普0.05 ml,再行Ahmed青光眼引流阀植入术,后择机行视网膜激光光凝,观察治疗前后视力、新生血管、眼压等情况。数据采用连续测量方差分析比较。术后各时间点眼压与术前比较采用独立样本t检验。结果:注药后3 d新生血管明显萎缩,1个月时,17眼新生血管全部消退。治疗前眼压为(43.3±7.6)mmHg(1 mmHg=0.133 kPa),联合治疗后3 d眼压为(14.8±4.8)mmHg,7 d时眼压为(13.7±3.9)mmHg,1个月时为(14.5±4.6)mmHg,3个月时为(13.6±5.4)mmHg,6个月时为(13.9±4.6)mmHg,不同时间点的眼压比较差异有统计学意义(F=9.58,P=0.006)。治疗后各个时间点眼压与治疗前相比差异均有统计学意义(P<0.05)。联合治疗后较治疗前,最佳矫正视力提高5眼。结论:玻璃体腔注射康柏西普联合Ahmed青光眼引流阀植入和视网膜光凝治疗NVG安全有效。
Objective:To observe the clinical effects of intravitreal injection of conbercept combined with Ahemd glaucoma valve implant and panretinal photocoagulation treatment for neovascular glaucoma(NVG).Methods:In this retrospective case series study,16 NVG patients(17 eyes),at the Number 986 Hospital of the Air Force,were treated from June,2017 to June,2018 with intravitreal injection of conbercept combined with Ahemd glaucoma valve implants and panretinal photocoagulation.The disappearance of neovascularization,intraocular pressure(IOP)and best corrected visual acuity(BCVA)were compared between preoperative and postoperative conditions.The data were analyzed by repeated measures ANOVA.The IOP between preoperative and every follow-up was analyzed with independent sample t test Results:After injection,neovascularization was greatly diminshed by 3 d,and completely vanished by 1 month.The preoperative IOP was 43.3±7.6 mmHg,and postoperative IOP was 14.8±4.8 mmHg,13.7±3.9 mmHg,14.5±4.6 mmHg,13.6±5.4 mmHg and 13.9±4.6 mmHg at 3 d,7 d,1 month,3 months,and 6 months,respectively.There were no significant differences in IOP at different postoperative time points(F=9.58,P=0.006).Compared with preoperative levels,there were significant differences at every followup(P<0.05).Compared with preoperative measurements,the BCVA of 5 eyes improved.Conclusions:Intravitreal injection of conbercept combined with Ahemd glaucoma valve implants and panretinal photocoagulation is a safe and effective treatment for neovascular glaucoma.
作者
海鸥
刘芳
高丹宇
Ou Hai;Fang Liu;Danyu Gao(The Number 986 Hospital of the Air Force,Xi'an 710018,China)
出处
《中华眼视光学与视觉科学杂志》
CAS
CSCD
2019年第11期838-841,共4页
Chinese Journal Of Optometry Ophthalmology And Visual Science
