摘要
目的应用Meta分析系统评价超声弹性成像鉴别诊断颈部淋巴结良恶性的价值。方法计算机检索Cochrane图书馆、PubMed、Embase、中国知网、万方、维普、中国生物医学文献数据库,搜索超声弹性成像鉴别诊断颈部淋巴结良恶性的相关文献,检索语言为英文和中文,检索时间为建库至2019年2月28日。对纳入文献进行异质性检验,并采用QUADAS量表进行质量评价。分析超声弹性成像鉴别诊断颈部恶性淋巴结的合并敏感性、特异性、阳性似然比、阴性似然比、诊断比值比,绘制汇总受试者工作特征(SROC)曲线,计算曲线下面积。结果最终纳入11篇文献,其中8篇中文文献,3篇英文文献,包括1134例患者,共1373个淋巴结。QUADAS量表评价显示,纳入文献质量较高。超声弹性成像鉴别诊断颈部恶性淋巴结的合并敏感性、特异性、阳性似然比、阴性似然比、诊断比值比分别为0.85(95%CI:0.83~0.87)、0.72(95%CI:0.68~0.76)、3.54(95%CI:2.19~5.71)、0.20(95%CI:0.13~0.32)、19.96(95%CI:8.85~45.04),SROC曲线下面积为0.9061。结论超声弹性成像对颈部淋巴结良恶性的鉴别诊断具有较高价值。
Objective To analyze the value of ultrasonic elastography in differentiating benign and malignant cervical lymph nodes by Meta analysis.Methods The databases including the PubMed,Embase,Cochrane,Wanfang,CNKI,Vip,CBM were searched from establishment to February 28,2019. The retrieval languages were English and Chinese.The literatures on differential diagnosis of benign and malignant cervical lymph nodes by real-time ultrasonic elastography were collected,the heterogeneity of all the included literatures was examined. The QUADAS scale was used for quality assessment.Pooled sensitivity,specificity,positive likelihood ratio and negative likelihood ratio were analyzed. The accuracy of ultrasonic elastography in differential diagnosis of cervical lymph nodes was evaluated by calculating the diagnostic ratio and the area under the curve(AUC)of the receiver operating characteristic(SROC)curve. Results A total of 11 articles were included,including 8 Chinese articles and 3 English articles.1134 patients were involved,with a total of 1373 lymph nodes. QUADAS scale showed the quality of all invdred articles were high. The pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and diagnostic odds ratio in the diagnosis of benign and malignant cervical lymph nodes were 0.85(95%CI:0.83~0.87),0.72(95%CI:0.68~0.76),3.54(95%CI:2.19~5.71),0.20(95%CI:0.13~0.32),19.96(95%CI:8.85~45.04),respectively. The AUC of SROC curve was 0.9061. Conclusion Ultrasonic elastography has high diagnostic value for differential diagnosis of benign and malignant cervical lymph nodes.
作者
曾祯
李欣龙
胡经纬
李璇
胡卫中
李明星
ZENG Zhen;LI Xinlong;HU Jingwei;LI Xuan;HU Weizhong;LI Mingxing(Department of Ultrasound,the Affiliated Hospital of Southwest Medical University,Sichuan 646000,China)
出处
《临床超声医学杂志》
CSCD
2019年第11期829-833,共5页
Journal of Clinical Ultrasound in Medicine
关键词
超声弹性成像
颈部淋巴结
良恶性
META分析
Ultrasonic elastography
Cervical lymph node,benign and malignant
Meta-analysis
