摘要
目的:比较左乙拉西坦与卡马西平对新诊断癫痫患者认知功能及复发的影响。方法:回顾性选取2017年4月至2018年1月延安大学附属医院收治的新诊断癫痫患者96例,根据治疗方式进行分组,A组48例患者采用左乙拉西坦治疗,B组48例患者采用卡马西平治疗。比较两组患者的脑电图疗效、认知功能改善情况、不良反应发生情况及复发情况的差异。结果:A、B组患者脑电图总有效率分别为97.92%(47/48)、95.83%(46/48),差异无统计学意义(P>0.05);治疗后,A组患者短时性记忆、言语能力及操作能力评分明显高于B组,差异均有统计学意义(P<0.05)。用药期间,A、B组患者不良反应发生率分别为4.17%(2/48)、8.33%(4/48),差异无统计学意义(P>0.05)。随访1年,A组患者的1年复发率为6.25%(3/48),明显低于B组的20.83%(10/48),差异有统计学意义(P<0.05)。结论:左乙拉西坦与卡马西平治疗新诊断癫痫的疗效相当,但左乙拉西坦能更好地改善患者的认知功能,减少疾病复发。
OBJECTIVE:To compare the effects of levetiracetam and carbamazepine on cognitive function and recurrence inpatients newly diagnosed with epilepsy.METHODS:96 patients newly diagnosed with epilepsy admitted into the Affiliated Hospital of Yan’an University from Apr.2017 to Jan.2018 were retrospectively selected and divided into two groups according to different therapeutic regimens,48 cases in group A was treated with levetiracetam,48 cases in group B was given carbamazepine.Differences in efficacy of electroencephalogram,improvements of cognitive function,incidences of adverse drug reactions and recurrence between two groups were compared.RESULTS:The total effective rates of group A and group B were respectively 97.92%(47/48)and 95.83%(46/48),the difference had no statistical significance(P>0.05);after treatment,the short-term memory,verbal ability and operational capacity of group A were significantly higher than those of group B,with statistically significant differences(P<0.05).During medication,the incidences of adverse drug reactions of group A and group B were respectively 4.17%(2/48)and 8.33%(4/48),the difference had no statistical significance(P>0.05).In 1-year follow-up,the recurrence rate of group A was 6.25%(3/48),which was significantly lower than that of group B(20.83%,10/48),with statistically significant difference(P<0.05).CONCLUSIONS:The efficacy of levetiracetam and carbamazepine in treatment of newly diagnosed epilepsy are similar,while levetiracetam has better effect in improving patients'cognitive function and reduce recurrence.
作者
师媛
屈文英
薛涛
刘莹莹
SHI Yuan;QU Wenying;XUE Tao;LIU Yingying(Dept.of Neurology,the Affiliated Hospital of Yanan University,Shaanxi Yan’an 716000,China)
出处
《中国医院用药评价与分析》
2019年第10期1227-1229,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
新诊断癫痫
左乙拉西坦
卡马西平
认知功能
复发
Newly diagnosed epilepsy
Levetiracetam
Carbamazepine
Cognitive function
Recurrence
