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沿海地区居民碘摄入情况与亚临床甲状腺功能减退的相关性分析 被引量:5

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摘要 目的探讨河北省秦皇岛市居民亚临床甲状腺功能减退患病与碘摄入的相关性。方法选择河北省秦皇岛市中医医院健康体检居民496例,其中男247例,女249例。根据居民日常食用加碘盐的情况分为加碘盐组(食用加碘盐连续食用≥5年,238例)和无碘盐组(食用无碘盐连续食用≥1年,258例);两组又根据居民海产品日常摄食情况各自分成海产品摄入高组(≥3次/周)和海产品摄入低组(≤2次/月)。分别检测各组游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free thyroxine,FT4)、促甲状腺激素(thyroid stimulating hormone,TSH)、甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPOAb)和甲状腺球蛋白抗体(Anti-thyroid autoantibodies,TGAb),并对检测结果进行统计学分析。结果 496例健康体检人群中,亚临床甲状腺功能减退的总体检出率为14.1%(70/496);加碘盐组中海产品摄入高组亚临床甲状腺功能减退的检出率(21.7%)显著高于海产品摄入低组(11.9%),差异有显著性(P<0.05);Logistic回归结果显示性别和海产品摄入高与亚临床甲状腺功能减退疾病显著相关(P<0.05),OR分别为3.794和2.596。结论经常食用含碘量高的海产品可能增加亚临床甲状腺功能减退的发病风险,碘摄入过量与亚临床甲状腺功能减退疾病呈现相关性。
出处 《中国临床医生杂志》 2019年第12期1489-1491,共3页 Chinese Journal For Clinicians
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