摘要
目的观察奥拉西坦联合脑苷肌肽治疗新生儿缺氧缺血性脑病的临床效果。方法选取2018年1~4月我院收治的80例新生儿缺氧缺血性脑病患儿作为研究对象,根据入院顺序分为观察组(40例)和对照组(40例)。对照组患儿采用静脉滴注脑苷肌肽注射液,观察组患儿在对照组的基础上,静脉滴注奥拉西坦注射液。比较两组患儿的临床体征改善情况及治疗效果。结果观察组患儿的后遗症总发生率为7.50%,低于对照组的25.00%,差异有统计学意义(P<0.05);观察组患儿的治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);观察组患儿肌张力异常、原始反射异常、意识障碍、惊厥、呼吸的改善时间均短于对照组,差异有统计学意义(P<0.05)。结论在新生儿缺氧缺血性脑病中应用脑苷肌肽及奥拉西坦联合治疗,可缩短患儿的肌张力异常改善时间、原始反射异常改善时间、意识障碍改善时间、惊厥改善时间、呼吸改善时间,降低后遗症的发生率,提高临床治疗效果,临床应用及推广价值极高。
Objective To observe the clinical effect of Oxiracetam combined with Cerebroside Carnosine in the treatment of neonatal hypoxic ischemic encephalopathy.Methods Eighty children with neonatal hypoxic ischemic encephalopathy treated in our hospital from January to April in 2018 were selected as the subjects.They were divided into observation group(40 cases)and control group(40 cases)according to the order of admission.The control group was treated with intravenous infusion of Cerebroside Carnosine Injection,and the observation group was treated with intravenous infusion of Oxiracetam Injection based on the control group.The clinical signs and treatment effects were compared between the two groups.Results The total incidence of sequelae in the observation group was 7.50%,which was lower than that of the control group(25.00%),and the difference was statistically significant(P<0.05).The total treatment effective rate of the observation group was 95.00%,which was higher than that of the control group(80.00%),and the difference was statistically significant(P<0.05).The improvement time of dystonia,primitive reflex,disturbance of consciousness,convulsion and respiration in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The combination of Cerebroside Carnosine and Oxiracetam in neonatal hypoxic ischemic encephalopathy can shorten the improvement of abnormal muscle tone,the improvement time of original reflex abnormality,the improvement time of consciousness disorder,the time of convulsion improvement,and the time of respiratory improvement,reduce the incidence of sequelae,improve the clinical treatment effect.The clinical application and promotion value is extremely high.
作者
陈卫平
林莉
徐阳
CHEN Wei-ping;LIN Li;XU Yang(Department of Pediatrics,Xiangyang Maternal and Child Health Care Hospital,Hubei Province,Xiangyang 441000,China;Department of Anesthesiology,Xiangyang First People′s Hospital Affiliated to Hubei Medical College,Hubei Province,Xiangyang 441000,China)
出处
《中国当代医药》
2019年第32期98-100,共3页
China Modern Medicine
关键词
新生儿
缺氧缺血性脑病
脑苷肌肽
奥拉西坦
Neonatal
Hypoxic ischemic encephalopathy
Cerebroside Carnosine
Oxiracetam
