摘要
目的应用星点设计-响应面法筛选川党参产地加工炮制一体化最佳工艺。方法以总黄酮、党参多糖、党参皂苷及党参炔苷的总评归一值为指标,利用星点设计响应面法,对切片含水量、干燥温度、干燥时间进行考察。结果川党参产地加工炮制一体化最佳工艺为新鲜党参药材经抢水洗,干燥至含水量46%,切制约为3 mm厚片,于58℃烘干10.71 h;通过DPPH自由基清除试验,该工艺生产的党参饮片相比于传统工艺生产的饮片具有更强的体外抗氧化活性。结论响应面法筛选川党参产地加工一体化工艺操作简便,有效成分损失相对较少,可为党参饮片的生产提供参考。
Objective To optimize the processing integration technology of Codonopsis tangshen Oliv.based on central composite design-response surface methodology.Methods Box-behnken design was used to optimize the integrative technology with the overall desirability value of four major characteristic components(total flavonoids,Codonopsis pilosula polysaccharides,Codonopsis pilosula saponins and lobetyolin)was used as index to detect three factors(water content,drying temperature and drying time).The radical scavenging capacities on DPPH of the samples processed with different methods were also studied.Results Optimum integrative technology of primary processing was washing the fresh C.tangshen quickly,drying to the water content of 46%,cutting into 3 mm pieces then drying at 58℃for 10.71 h.The scavenging ability on DPPH of the samples processed by the established method was higher than that using traditional processing method.Conclusion The optimized integrative technology of C.tangshen is more convenient to operate and it can reduce the loss of the chemical composition during processing.It could provide the innovative idea to produce C.tangshen slices.
作者
郭振宇
张毅
张正锋
杨军宣
GUO Zhenyu;ZHANG Yi;ZHANG Zhengfeng;YANG Junxuan(TCM School of Chongqing Medical University,Chongqing 400016,China;Chongqing Institute for Food and Drug Control,Chongqing 401121,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2019年第11期1385-1390,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家药典委员会项目（ZG2016-2-06）
重庆市卫生与计划生育委员会项目（ZY201702132）
关键词
川党参
响应面法
产地加工炮制一体化
抗氧化活性
Codonopsis tangshen Oliv.
response surface methodology
integrative technology of primary processing
antioxidant activity
