摘要
目的观察PCI术前应用杏芎氯化钠注射液治疗急性心肌梗死患者的临床效果。方法回顾性收集2017年3月至2019年2月我科收治的268例急性心肌梗死患者的临床资料,根据是否在PCI术前应用杏芎氯化钠注射液将其分成观察组(n=122)和对照组(n=146)。两组患者均进行抗凝治疗,对照组在PCI术前0.5 h口服阿司匹林肠溶片(300 mg)、硫酸氢氯吡格雷(75 mg)、瑞舒伐他汀(20 mg);观察组在对照组基础上于PCI术前2 h静脉滴注杏芎氯化钠注射液(250 mL)。观察两组患者PCI术后胸痛症状改善和心电图ST段回落情况,比较给药前、手术后的ET-1、vWF及NO水平。结果两组患者PCI术后的胸痛症状改善情况差异不显著(χ^2=0.021,P=0.886);对照组126例(86.30%)患者ST段回落,观察组115例(94.26%)ST段回落,观察组患者的心电图ST段回落情况显著优于对照组(χ^2=4.649,P=0.031)。给药前,两组患者的ET-1水平比较,差异无统计学意义(P>0.05);手术后,两组患者ET-1水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。给药前,两组患者的vWF水平比较,差异无统计学意义(P>0.05);手术后,两组患者vWF水平均显著降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。给药前,两组患者的NO水平比较,差异无统计学意义(P>0.05);手术后,两组患者NO水平均显著升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。结论急性心肌梗死患者PCI术前给予杏芎氯化钠注射液干预可以显著缓解患者的临床症状,降低术后血清中ET-1和vWF水平,升高NO水平,具有较好的临床效果。
Objective To observe the clinical effect of Xingxiong sodium chloride injection on patients with acute myocardial infarction before PCI. Methods The clinical data of 268 patients with acute myocardial infarction admitted in our department from March 2017 to February 2019 were collected retrospectively. According to whether Xingxiong sodium chloride injection was used before PCI, the patients were divided into observation group(n=122) and control group(n =146). Both groups of patients were treated with anticoagulation. The control group took aspirin enteric coated tablets(300 mg), clopidogrel bisulfate(75 mg) and rosuvastatin(20 mg) at 0.5 h before PCI, and the observation group took Xingxiong sodium chloride injection(250 mL) at 2 h before PCI on the basis of the control group. The improvement of chest pain symptoms and ST segment depression of electrocardiogram after PCI between the two groups were observed,and the levels of ET-1, vWF and NO before administration and after operation were compared. Results There was no significant difference in the improvement of chest pain symptoms between the two groups after PCI(χ^2=0.021, P=0.886);126 patients(86.30%) experienced ST segment depression in the control group, 115 patients(94.26%) experienced ST segment depression in the observation group, the ST segment depression of electrocardiogram in the observation group was significantly better than that in the control group(χ^2=4.649, P =0.031). Before administration, there was no significant difference in the level of ET-1 between the two groups(P>0.05);after operation, the level of ET-1 in the two groups reduced, and that in the observation group was lower than the control group, the difference was statistically significant(P<0.05). Before administration, there was no significant difference in the level of vWF between the two groups( P>0.05);after operation, the level of vWF in the two groups reduced, and that in the observation group was lower than the control group, the difference was statistically significant(P <0.05). Before administration, there was no significant difference in the level of NO between the two groups(P>0.05);after operation, the level of NO in the two groups increaseed, and that in the observation group was higher than the control group, the difference was statistically significant(P <0.05).Conclusion The intervention of Xingxiong sodium chloride injection before PCI can significantly alleviate the clinical symptoms of patients with acute myocardial infarction, reduce the levels of ET-1 and vWF in serum, and increase the level of No, which has good clinical effect.
作者
李军
曾广伟
姚远
杨沛
廉诚
侯小四
LI Jun;ZENG Guang-wei;YAO Yuan;YANG Pei;LIAN Cheng;HOU Xiao-si(Internal Medicine-Cardiovascular Department,Tangdu Hospital,Air Force Military Medical University,Xi'an 710038;Internal Medicine-Cardiovascular Department,Basic Medicine College of Air Force Military Medical University 5th Brigade,Xi'an 710038;Internal Medicine Department,94750 PLA Military Hospital,Longyan 366200,China)
出处
《临床医学研究与实践》
2019年第34期25-27,30,共4页
Clinical Research and Practice
基金
陕西省重点研发计划项目（No.2018SF-085）
关键词
急性心肌梗死
PCI术
杏芎氯化钠注射液
acute myocardial infarction
PCI operation
Xingxiong sodium chloride injection
