摘要
紫草素具有抗肿瘤活性,不仅可抑制胶质瘤细胞的增殖、迁移与浸润,还可通过诱导活性氧簇生成等促进胶质瘤发生程序性坏死。紫草素联合内质网应激抑制剂及调控微小RNA表达可进一步提高其对胶质瘤的杀伤效应,通过纳米颗粒修饰紫草素有助于增强其对胶质瘤的靶向性。紫草素联合靶向治疗药物或化疗药物有望克服胶质瘤细胞的耐药问题。
Shikonin has anti-tumor activity,and it not only can inhibit the proliferation,migration and infiltration of glioma cells,but also induce necroptosis of glioma cells via promoting the production of reactive oxygen species.Shikonin combined with endoplasmic reticulum stress inhibitors or regulatory tactics of micro-RNA expression may further enhance its killing effect on gliomas.Shikonin armed by nanoparticles shows increased targetability to gliomas.Shikonin combined with tumor-targeted therapeutic drugs or chemotherapeutic drugs is expected to overcome the drug resistance of glioma cells.
作者
衣琳
邱实
Yi Lin;Qiu Shi(Department of Geriatric Medicine,General Hospital of Jilin Chemical Industry Group of Jilin City of Jilin Province,Jilin 132021,China;Department of Radiotherapy and Chemotherapy,General Hospital of Jilin Chemical Industry Group of Jilin City of Jilin Province,Jilin 132021,China)
出处
《国际肿瘤学杂志》
CAS
2019年第8期489-491,共3页
Journal of International Oncology
关键词
神经胶质瘤
紫草素
活性氧
抗肿瘤药
程序性坏死
Gliomas
Shikonin
Reactive oxygen species
Antineoplastic agents
Necroptosis
