摘要
目的了解初发儿童急性淋巴细胞白血病住院病例的发病情况和流行病学特征。方法回顾性分析2008年-2018年586例15岁以下初发急性淋巴细胞白血病住院患者的流行病学资料。结果2008年1月1日-2018年12月31日儿童急性淋巴细胞白血病,在同时期儿童白血病和恶性肿瘤中的发病情况总体呈上升趋势。其亚型分布以L2型为主,免疫表型以B系表达为主,核型异常率为44.35%,融合基因异常率为45.07%。城市高于农村。男性发病率高于女性。发病高峰为4岁~6岁,占38.74%,急性淋巴细胞白血病患儿各年龄组发病差异具有统计学意义(P<0.05)。结论急性淋巴细胞白血病患儿的形态学类型、免疫学分型、细胞遗传学检查、融合基因类型存在差异性,而不同年龄、性别、地区和发病季节对儿童急性淋巴细胞白血病的发病有影响。
Objective To analyze the incidence and epidemiological characteristics of 586 cases newly diagnosed childhood acute lymphoblastic leukemia(ALL) in Ningxia from 2008 to 2018.Methods The records of 586 children under 15 years with ALL hospitalized patients who were newly diagnosed from 2008 to 2018.Results The children ALL was on the rise between children leukemia and malignant tumors in the same period from 2008 to 2018.The ALL subtype distribution was dominated by the L2,the immune phenotype was mainly expressed in B-cell ALL,44.35% patients had cloning abnormalities and the abnormal rate of fusion was 45.07%.The incidence of han is higher than the hui nationality,the city is higher than the rural area and the males is higher than female.ALL was most common in 4~6 years age group,accounted for 38.74%,the difference of incidence was statistically significant in ALL subtypes(P<0.05).The differences in ALL subtypes were statistically significant with each year(P<0.05).Conclusion ALL children ’ s morphological types,immunological credit types,cytogenetic examination and fusion gene types are different,while different ages,genders,races,regions and seasons have influence on the incidence of ALL in children.
作者
龚爱红
邸益红
王晓佳
方浩
Gong Aihong;Di Yihong;Wang Xiaojia;Fang Hao(Medical Records and Statistics Department,General Hospital of Ningxia Medical University,Yinchuan 750004,Ningxia Hui Autonomous Region,China)
出处
《中国病案》
2019年第10期59-62,共4页
Chinese Medical Record
基金
宁夏自然科学基金(NZ16138)
关键词
儿童
急性淋巴细胞白血病
回顾性分析
Childhood
Acute lymphoblastic leukemia(ALL)
Retrospective analysis
