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氨磺必利治疗首发精神分裂症的临床疗效及其对患者认知功能的影响

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摘要 目的探讨氨磺必利治疗首发精神分裂症的临床疗效及其对患者认知功能的影响。方法选取湘西自治州精神病医院2017年收治的首发精神分裂症患者98例,采用随机数字表法分为对照组48例与观察组50例。对照组患者予以利培酮分散片治疗,观察组患者予以氨磺必利片治疗,两组患者均连续治疗2个疗程。比较两组患者临床疗效,治疗前后精神分裂症认知功能成套测验(MCCB)评分和韦氏成人记忆量表(WMS-RS)评分,治疗前后社会功能缺陷筛选量表(SDSS)评分和生活质量综合评定量表(GQOLI-74)评分。结果两组患者治疗总有效率比较,差异无统计学意义(P>0.05)。治疗前两组患者MCCB评分和WMS-RS评分比较,差异无统计学意义(P>0.05);治疗后观察组患者MCCB评分和WMS-RS评分高于对照组(P<0.05)。治疗前两组患者SDSS评分和GQOLI-74评分比较,差异无统计学意义(P>0.05);治疗后观察组SDSS评分低于对照组,GQOLI-74评分高于对照组(P<0.05)。结论氨磺必利治疗首发精神分裂症的临床疗效确切,可改善患者认知、记忆、社会功能,提高其生活质量。
作者 向永红
出处 《临床合理用药杂志》 2019年第30期93-94,共2页 Chinese Journal of Clinical Rational Drug Use
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