摘要
肝细胞癌是世界上最常见的恶性肿瘤。尽管肝癌在诊断和治疗方面取得了一些进展,但由于不易被早期诊断并且病情进程快,仍然是全球癌症死亡的第三大原因。中国亦是肝癌的高发地区,发病人数较多且呈上升趋势,防治形势相当严峻。目前,西医对于肝癌复杂发病机制与临床治疗思路尚不清晰,仍然存在许多短板并面临着巨大的挑战,而中医药在治疗肝癌方面具有其独特的优势,讲究整体观念,对于肝癌的治疗功效独特、副作用相对较小;不仅可以抑制肿瘤生长,还能改善患者的临床症状并提高其生存质量。因此,中医药方剂治疗肝癌的研究吸引了无数临床工作者和科研学者们的目光。但是中药复方的化学成分复杂,作用靶点多,发挥药效机制网络庞大,极大地限制了学者们对其的深入研究与临床用药开发。近年来,中药复方在抗肝癌的药效与作用机制研究方面也取得了一些成果,主要集中在复方对肝癌细胞的抑制增殖作用、阻滞细胞周期和诱导细胞凋亡与自噬作用、抑制肝癌细胞侵袭和转移、调节免疫功能、增效减毒和逆转耐药性等方面。该文对中药复方抗肝癌上述药效与作用机制的国内外文献进行检索,并进行分析、归纳与总结,现就其抗肝癌的作用机制研究进展作简要综述,为今后中药复方抗肝癌的作用机制研究及其临床合理应用提供科学思路与依据。
Hepatocellular carcinoma(HCC)is the most common malignancy in the world.Although there is progress in HCC diagnosis and treatment,it is still the third leading cause of cancer death worldwide because it is not easily diagnosed early and the disease progresses quickly.China is a high-risk area for HCC,and the number of cases is high and on the rise.Its prevention and treatment is a pressing problem.At present,western medicine is still unclear about the complex pathogenesis and clinical treatment of HCC.There are still many shortcomings and huge challenges.Traditional Chinese medicine(TCM)has its unique advantages in the treatment of HCC.With an overall concept,it has unique therapeutic effect and fewer side effect on HCC,it can not only inhibit tumor growth,but also alleviate patients’clinical symptoms and improve their quality of life.Therefore,the study of the effect of TCM in treating HCC has attracted the attention from many clinicians and researchers.However,the chemical composition of TCM formula is complex,with many targets and huge network of pharmacodynamic mechanisms,which greatly limits the research on the development of clinical drugs for the Chinese medicine formula.In recent years,there have been achievements in the studies of anti-hepatocarcinoma efficacy and mechanism of action of Chinese medicine compound,which mainly focused on the compound’s effect in inhibiting the proliferation of hepatocarcinoma cells,blocking cell cycle and inducing apoptosis and autophagy,inhibiting liver cancer cell invasion and metastasis,regulating the immune function,synergism and attenuation,and reversing the drug resistance.In this paper,domestic and foreign literatures on the above-mentioned pharmacodynamics and mechanism of anti-liver cancer of TCM compound were studied,analyzed,summarized and summarized.This paper briefly reviews the research progress of its anti-hepatocarcinoma mechanism,and provides scientific ideas and evidence for the future study of the anti-hepatocarcinoma mechanism of TCM compound and its rational clinical application.
作者
徐菲
曾杨丽
李娟
蔡思
唐玺
王智
肖利辉
李顺祥
XU Fei;ZENG Yang-li;LI Juan;CAI Si;TANG Xi;WANG Zhi;XIAO Li-hui;LI Shun-xiang(Hunan Province Engineering Research Center of Bioactive Substance Discovery of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;KAMP Medicine Co.Ltd.,Changsha 410008,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2019年第24期196-204,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
湖南省科技计划项目(2016SK2033)
长沙市科技局计划项目(kp1801043)
湖南省中医药管理局重点项目(201614)
湖南中医药大学中药学一流学科(校行科字[2018]3号)
湖南中医药大学中药学一流学科开放基金项目(2018ZYX02)
湖南省教育厅项目(14C0861)
关键词
中药复方
防治肝癌
肝细胞癌
抑制肝癌肿瘤
作用机制
traditional Chinese medicine compound
prevention and treatment of liver cancer
hepatocellular carcinoma
inhibiting liver cancer tumors
mechanism
