摘要
目的探讨射频消融术联合化疗治疗进展期非小细胞肺癌的近远期效果及对患者复发率的影响.方法选取佛山市第一人民医院2013年1月至2015年1月收治的60例进展期非小细胞肺癌患者,随机分为对照组与观察组,每组30例.对照组实施GP方案化疗,观察组实施GP方案化疗+射频消融术治疗,比较两组的近期疗效、癌因性疼痛评分、癌因性疲乏评分、中远期存活率、局部复发率、生存质量评分.结果观察组客观缓解率、总有效率均高于对照组(P均<0.05).治疗后,两组静息疼痛评分、运动疼痛评分均低于治疗前(P<0.05),而观察组静息疼痛评分、运动疼痛评分均低于对照组(P均<0.05).治疗后观察组癌因性疲乏评分低于对照组(P<0.05).观察组1年存活率、3年存活率均高于对照组(P均<0.05).观察组治疗后1年、3年的的局部复发率均低于对照组(P均<0.05).随访1年、3年时,观察组的生理健康、精神健康、社会功能、总体感觉等生存质量评分均高于对照组(P均<0.05).结论对进展期非小细胞肺癌患者,应用化疗联合射频消融术治疗,可取得良好的近期疗效,减轻患者癌因性疼痛和疲乏状况,还可有效提高患者中远期存活率,减少其局部复发,改善其生存质量.
Objective To study the short-term and long-term efficacy of radiofrequency ablation combined with chemotherapy in the treatment of advanced non-small cell lung cancer.Methods A total of 60 patients with advanced non-small cell lung cancer treated from January 2013 to January 2015 in Foshan First People's Hospital were selected.The 60 patients were randomly divided into control group(n=30)and observation group(n=30).The control group received GP regimen chemotherapy and the observation group received radiofrequency ablation and GP regimen chemotherapy.The short-term curative effect,cancer pain score,cancer-induced fatigue score,medium and long term survival rate,local recurrence rate and quality of life score were compared between the two groups.Results The objective remission rate and total effective rate of the observation group were higher than those of the control group(P<0.05).The scores of resting pain and motor pain after teatment in the two groups were lower than those before treatment(P<0.05),and the score of resting pain and motor pain in the observation group were lower than those in the control group(P<0.05).After treatment,the score of cancer-related fatigue in the observation group was lower than that in the control group(P<0.05).The 1-year and 3-year survival rates of the observation group were higher than those of the control group(P<0.05).The local recurrence rate of the observation group was lower than that of the control group 1 and 3 years after treatment(P<0.05).The scores of physical health,mental health,social function and general feeling in the observation group were higher than those in the control group(P<0.05).Conclusions In patients with advanced non-small cell lung cancer,chemotherapy combined with radiofrequency ablation can obtain good short-term curative effect,alleviate the pain and fatigue due to cancer,and improve the survival rate of patients in the medium and long term.The local recurrence is reduced and the quality of life is improved.
作者
彭国文
Peng Guowen(Department of Tumor Targeting Intervention,Foshan First People’s Hospital,Foshan 528000,China)
出处
《中国实用医刊》
2019年第20期82-85,共4页
Chinese Journal of Practical Medicine
关键词
非小细胞肺癌
化疗
射频消融术
近期效果
Non-small cell lung cancer
Chemotherapy
Radiofrequency ablation
Short term effect
