摘要
目的:探讨多发性骨髓瘤(MM)采用以万珂为主联合环磷酰胺化疗方案的临床治疗效果。方法:2015年8月-2019年8月收治MM患者102例,随机分为两组。观察组采用万珂+环磷酰胺+地塞米松联合化疗,对照组采用万珂+地塞米松化疗。对比两组2个疗程后的临床疗效与化疗治疗期间的不良反应。结果:观察组治疗2个疗程后总有效率高于对照组,差异有统计学意义(P<0.05)。观察组感染、胃肠道不良反应总发生率显著高于对照组,差异有统计学意义(P<0.05)。结论:以万珂为主联合环磷酰胺化疗方案应用于MM患者疗效确切,适用于临床推广及应用,但同时肺部感染、消化道症状等药物不良反应也明显增加,部分老年人不能耐受。
Objective:To explore the clinical effect of combination chemotherapy with Vanke and cyclophosphamide for multiple myeloma.Methods:102 patients with multiple myeloma were selected from August 2015 to August 2019,they were randomly divided into the two groups.The observation group was treated with Vanke+cyclophosphamide+dexamethasone combined chemotherapy.The control group was treated with Vanke+dexamethasone.The efficacy of the two groups after 2 courses of treatment and the adverse reactions during chemotherapy treatment were compared.Results:The total effective rate after 2 courses of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The total incidence of infection in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).The total incidence of gastrointestinal reactions in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The effect of Vanke combined with cyclophosphamide as the main chemotherapy regimen in patients with multiple myeloma is more accurate,it is suitable for clinical application.But at the same time,the adverse drug reactions such as pulmonary infection and gastrointestinal symptoms also increased significantly,which could not be tolerated by some elderly people.
作者
陈丽
胡慧仙
翁翔
雷艳敏
Chen Li;Hu Huixian;Weng Xiang;Lei Yanmin(Jinhua Central Hospital,Zhejiang Jinhua 321000)
出处
《中国社区医师》
2019年第34期13-14,共2页
Chinese Community Doctors
