摘要
目的探究和分析糖皮质激素联合特布他林治疗急性加重期慢阻肺的临床效果。方法选择该院82例急性加重期慢阻肺患者作为研究对象(收治时间范围为2018年1—12月),患者分组采用单双号法进行,单号为对照组,双号为研究组。每组41例,对照组采用特布他林治疗,研究组采用糖皮质激素联合特布他林治疗,对比两组患者治疗前后用力肺活量(FVC)、第1秒用力呼气容积(FEV1)等肺功能指标水平、两组患者喘息、咳嗽、呼吸困难等症状改善时间及治疗的总有效率。结果研究组患者FVC(2.9±0.8)L、FEV1(2.3±0.9)L等肺功能指标水平显著高于对照组(2.2±0.6)L、(1.4±0.6)L(t=9.869、8.817,P<0.05),研究组患者喘息、咳嗽、呼吸困难等症状改善时间(2.5±0.7)d、(4.1±1.3)d、(2.3±0.4)d均显著短于对照组(5.6±1.0)d、(8.6±2.1)d、(5.2±0.8)d,(t=8.946、9.253、7.484,P<0.05)研究组患者治疗的总有效率(92.7%)显著高于对照组(75.6%),两组对比差异有统计学意义(χ^2=7.629,P<0.05)。结论对急性加重期慢阻肺患者采用糖皮质激素联合特布他林治疗,不但能有效改善患者肺通气功能,还能提升其整体预后效果。
Objective To investigate and analyze the clinical effects of glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods Eighty-two patients with acute exacerbation of chronic obstructive pulmonary disease were enrolled in our hospital(the time range was from January to December 2018). The patients were divided into single and double numbers. The single number was the control group and the research group, 41 patients/group, the control group was treated with terbutaline, and the study group was treated with glucocorticoid combined with terbutaline. The two groups were compared with the forced vital capacity(FVC) before and after treatment, and the forced expiratory volume(FEV1) in the first second. The level of lung function indicators, the time to improve symptoms such as wheezing, coughing, and dyspnea in the two groups and the total effective rate of treatment. Results The levels of FVC(2.9±0.8)L and FEV1(2.3±0.9)L in the study group were significantly higher than those in the control group(2.2±0.6)L and(1.4±0.6)L(t=9.869,8.817, P<0.05), the improvement time of symptoms such as wheezing, cough and dyspnea in the study group(2.5 ±0.7)d,(4.1±1.3)d,(2.3±0.4)d were significantly shorter than the control group(5.6±1.0)d.(8.6±2.1)d,(5.2±0.8)d(t=8.946,9.253,7.484, P<0.05) The total effective rate of treatment in the study group(92.7%) was significantly higher than that of the control group(75.6%). The two groups were statistically significant(χ^2=7.629, P <0.05). Conclusion The treatment of glucocorticoid combined with terbutaline in patients with acute exacerbation of chronic obstructive pulmonary disease can not only improve the lung ventilation function, but also improve the overall prognosis.
作者
冯莉
FENG Li(Wanzhou District Hospital of Chongqing Municipality,Chongqing,404000 Chin)
出处
《系统医学》
2019年第21期39-41,共3页
Systems Medicine
关键词
糖皮质激素
特布他林
急性加重期慢阻肺
Glucocorticoid
Terbutaline
Acute exacerbation of chronic obstructive pulmonary disease
