摘要
目的探讨类风湿性关节炎(rheumatoid arthritis,RA)患者抗环瓜氨酸肽(anti-cyclic citrullinated peptide,ACCP)抗体与超声检出的骨侵蚀的相关性。方法对符合1987年RA分类标准的RA患者的双侧腕关节、第1~5掌指关节及第2~3近节指间关节进行常规灰阶超声和能量多普勒(power Doppler,PD)超声检查,观察关节骨侵蚀、滑膜增厚及PD血流信号情况,分析ACCP抗体阳性和阴性患者的骨侵蚀、滑膜增厚、PD血流信号评分之间的差异,并探讨ACCP、病程与骨侵蚀的关系。结果RA患者101例,其中女性81例,ACCP抗体阳性患者75例,ACCP抗体阳性组与阴性组的骨侵蚀总评分在两组间差异有统计学意义(P=0.009),而滑膜增厚及PD血流信号总评分在两组间差异无统计学意义。在病程>3年的患者中,ACCP抗体阳性组与阴性组之间的骨侵蚀总评分差异有统计学意义(P=0.01)。结论ACCP抗体阳性、病程>3年的RA患者有较高的骨侵蚀评分。
Objective To explore the relationship between the anti-cyclic citrullinated peptide(ACCP)antibody and bone erosion in patients with rheumatoid arthritis(RA).Methods One hundred and one RA patients were enrolled.Eighty-one of these patients were female,and 75 cases were ACCP positive.Gray scale(GS)and power Doppler(PD)ultrasound was performed to assess bone erosion,synovial hypertrophy,and PD signal.The bilateral wrists,I-V metacarpophalangeal joints,Ⅱ-Ⅲmetacarpophalangeal joints of the hands were detected by GS and PD ultrasound.Appropriate statistical analysis methods were used to analyze the difference of ultrasonographic characteristics in ACCP-positive and ACCP-negative patients,and explore the relationship of the ACCP antibody,disease duration with bone erosion.Results Bone erosion score in ACCP-positive patients was significantly greater than in ACCP-negative patients(P=0.009).No statistically significant difference was observed in synovial hypertrophy and PD signal between ACCP-positive patients and ACCP-negative patients.In RA patients with a disease duration>3 years,however,bone erosion score in ACCP-positive patients was significantly greater than that in ACCP-negative patients(P=0.01).Conclusion ACCP-positive RA patients with a disease duration>3 years had higher bone erosion score.
作者
李文雪
刘芳
朱家安
刘芳
陈征
李殿城
Li Wenxue;Liu Fang;Zhu Jiaan;Liu Fang;Chen Zheng;Li Diancheng(Department of Ultrasound,Peking University People's Hospital,Beijing 100044,China;Ruian People's Hospital,Wenzhou 325200,Zhejiang Province,China)
出处
《首都医科大学学报》
CAS
北大核心
2019年第6期829-832,共4页
Journal of Capital Medical University
基金
国家自然科学基金(81571684)
北京大学人民医院研究与发展基金(RDY2017-35)~~
关键词
类风湿性关节炎
抗环瓜氨酸肽抗体
超声
骨侵蚀
rheumatoid arthritis
anti-cyclic citrullinated peptide antibody
ultrasonography
bone erosion
