摘要
目的研究癌胚抗原相关细胞黏附分子5(carcinoembryonic antigen related adhesive molecular 5,CEACAM 5)及增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)在唾液腺腺样囊性癌(adenoid cystic carcinoma,ACC)中的表达,并分析其与临床预后的关系。方法应用免疫组织化学SP法检测54例唾液腺ACC、30例SPA、30例癌旁正常唾液腺组织CEACAM 5与PCNA的表达,并分析两者的相关性,随访并记录54例ACC患者的生存时间,采用Kaplan-Meier生存曲线进行预后评估。结果CEACAM 5与PCNA在ACC组中阳性表达率均明显高于SPA组和癌旁正常唾液腺组(P<0.01);CEACAM 5与PCNA的表达与ACC病理类型、TNM分期、转移、神经侵犯等病理特征密切相关(P<0.01),而与性别、年龄、部位无相关性(P>0.05);唾液腺ACC中CEACAM 5与PCNA的表达呈正相关(rs=0.703,P=0.000)。且两者均阴性表达患者的生存时间均明显长于阳性患者(P<0.01)。结论唾液腺ACC中CEACAM 5和PCNA的表达水平可能对评估ACC的恶性程度和患者的预后有一定指导意义。
Objective To investigate the the expression of CEACAM 5 and PCNA in adenoid cystic carcinoma of salivary glands,and to investigate the relationships of their expression and the clinical prognosis.Methods The expression of CEACAM 5 and PCNA in 54 cases of ACC,30 cases of SPA and 30 cases of tumor adjacent normal tissues were detected by immunohistochemical method,and the correlation between their expression was analyzed.The 54 patients were followed up and recorded their survival time,and prognostic evaluation was performed by using Kaplan-Meier survival curve.Results The positive expressions of CEACAM 5 and PCNA were higher in ACC tissues than those in SPA tissues and in tumor adjacent normal tissues(P<0.01).The expression of CEACAM 5 and PCNA were significantly associated with histological types,the clinical stage of TNM,metastasis and neural invasion(P<0.05).There were no significant difference beween the positive expression of CEACAM 5 and PCNA in the groups of different gender,age and tumor sites(P>0.05).There was a positive correlation beween the positive expression of CEACAM 5 and PCNA in ACC tissues.In ACC of salivary glands group,patients with negative CEACAM 5 and PCNA expression have significantly longer survival than those with positive expression(P<0.01).Conclusion In ACC of salivary glands,abnormally high expression of CEACAM 5 and PCNA may synergistically regulate tumor proliferation,affecting the malignant degree of tumor and the prognosis of patients.
作者
马赛
安峰
刘振丽
张璇
刘博
张慧
MA Sai;AN Feng;LIU Zhenli;ZHANG Xuan;LIU Bo;ZHANG Hui(Department of Stomatology,the First Affiliated Hospital of Hebei North College,Zhangjiakou 075000)
出处
《现代口腔医学杂志》
CAS
2019年第6期324-327,359,共5页
Journal of Modern Stomatology
基金
张家口市2019年度市级科技计划自筹经费项目(1921054D)
