摘要
目的 探讨双嘧达莫联合泼尼松治疗小儿肾病综合征的临床疗效及对肾功能和凝血系统的影响。方法回顾性选取2016年8月至2019年8月宝鸡市妇幼保健院儿五科收治的肾病综合征患儿210例,按照治疗方法不同分为联合治疗组(n=105)和单独治疗组(n=105),联合治疗组患儿采用双嘧达莫联合泼尼松治疗,单独治疗组患儿采用单独泼尼松治疗。统计分析两组患儿的肾功能、凝血功能和临床疗效。结果 治疗后,联合治疗组患儿24 h尿蛋白定量、Scr、BUN水平[(0. 8±0. 2) g、(72. 4±6. 1)μmol/L、(7. 0±0. 5) mmol/L]和单独治疗组4 h尿蛋白定量、Scr、BUN水平[(1. 8±0. 5) g、(88. 5±6. 8)μmol/L、(8. 1±0. 55) mmol/L]均较治疗前明显降低,两组Cer水平[联合治疗组:(64. 3±4. 1) ml/min,单独治疗组:(54. 2±4. 1) mi/min]均较治疗前明显升高,差异有显著性(P <0. 05),且联合治疗组患儿治疗后的24 h尿蛋白定量、Scr、BUN水平降低幅度、Cer升高幅度均显著高于单独治疗组,差异具有统计学意义(P<0. 05)。治疗后联合治疗组患儿活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)[(31. 9±2. 7) s、(14. 9±2. 5) s]和单独治疗组患儿APTT、PT[(32. 7±2. 4) s、(14. 9±2. 6) s]均较治疗前明显升高,差异有显著性(P <0. 05);且治疗后两组患儿的APTT、PT无显著差异(P> 0. 05)。联合治疗组总有效率(90. 5%)明显高于单独治疗组(80. 0%),差异有统计学意义(P <0. 05)。结论 小儿肾病综合征应用双嘧达莫联合泼尼松治疗的临床疗效较单独泼尼松治疗显著,更能有效改善患儿的肾功能和凝血系统。
Objective To explore the clinical effect of Dipyridamole combined with Prednisone in the treatment of nephrotic syndrome in children and its influences on renal function and coagulation system.Methods A total of 210 cases of children with nephrotic syndrome from August 2016 to August 2019 in Five departments of Pediatrics of Baoji maternal and Child Health Hospital were divided into two groups,including dipyridamole combined with prednisone(combined treatment group,n=105)and prednisone alone(single treatment group,n=105)according to different treatment methods.The renal functions,coagulation functions and clinical effects of the two groups were statistically analyzed.Results After treatment,24 h urine protein quantitative SCR and BUN levels[(0.8±0.2)g,(72.4±6.1)μmol/L,(7.0±0.5)mmol/L]in the combined treatment group and 4 h urine protein quantitative SCR and BUN levels[(1.8±0.5)g,(88.5±6.8)μmol/L,(8.1±0.55)mmol/L]in the single treatment group were significantly lower than those before treatment,and CER levels in the two groups[(64.3±4.1)ml/min in the combined treatment group,treated alone Group(54.2±4.1)mi/min]was significantly higher than that before treatment(P<0.05).After treatment,APTT,Pt in the combined treatment group were[(31.9±2.7)s,(14.9±2.5)s]and APTT,Pt[(32.7±2.4)s,(14.9±2.6)s]respectively.There was no significant difference in APTT and Pt between the two groups(P>0.05).The total effective rate of the combined treatment group(90.5%)was significantly higher than that of the single treatment group(80.0%),the difference was statistically significant(P<0.05).Conclusion The clinical effect of Dipyridamole combined with Prednisone in children with nephrotic syndrome is more significant than prednisone alone,and it can improve the renal function and coagulation system of the patients more effectively.
作者
薛坤
李小敏
任晓红
王英莉
付亚妮
XUE Kun;LI Xiao-min;REN Xiao-hong(Five departments of Pediatrics,Baoji Maternal and Child Health Care Hospital,Baoji Shaanxi 721000,China)
出处
《临床和实验医学杂志》
2019年第24期2662-2665,共4页
Journal of Clinical and Experimental Medicine
基金
陕西省卫生厅科研基金项目(编号:2016JM6029)
关键词
小儿肾病综合征
泼尼松
双嘧达莫
肾功能
凝血系统
Nephrotic syndrome in children
Prednisone
Dipyridamole
Renal function
Coagulation system
