摘要
目的通过系统评价再评价探讨酒精使用对消化系统癌症的影响。方法计算机检索PubMed、Embase、中国知网(CNKI)、万方数据知识服务平台、维普全文数据库等数据库,检索时限为建库至2017年8月31日,检索酒精或饮酒与消化疾病相关的系统评价和Meta分析,采用AMSTAR工具评价纳入研究的方法学质量。结果最终纳入17篇系统评价/Meta分析,4篇评价了酒精使用与胃癌的影响,7篇评价了酒精使用与食管相关疾病的影响,1篇评价了酒精使用与胰腺癌的相关影响,1篇评价了酒精使用与咽癌的影响,1篇评价了酒精使用与上消化道癌症的影响,1篇评价了酒精使用与口腔癌的影响,2篇评价了酒精使用与/肠直肠癌的影响。14篇报告了纳入人群的样本量,但所有系统评价/Mata分析均未报告人群的年龄。6篇对纳入研究进行了方法学质量评价,并阐述质量评价工具。结论综合纳入的17篇系统评价,发现过量饮酒有可能增加患胃癌,胰腺癌风险,甚至增加胰腺癌患者的病死率,并与口腔癌,结肠直肠癌的发病率显著相关。当前纳入针对饮酒与消化系统癌症的系统评价质量总体不高,结论的证据水平普遍较低,所得结论尚需更加大量样本来验证。临床医生使用本研究证据需谨慎。
Objective To revaluate systematic reviews of the impact to digestive system tumors from alcohol use.Methods We electronically searched databases including PubMed,Embase,CNKI,WanFang and VIP to collect systematic reviews and meta-analysis about alchol and digestive system from inception to August 31st 2017.Two reviewers independently screened literature and extracted data,then AMSTAR tool was used to assess the methodological quality of included studies.Results 17 systematic reviews or Meta analysis were included eventually,the effects of alcohol use to gastric cancer were evaluated in 4 articles and the effects of alcohol use on esophageal related diseases were evaluated in 7 articles.The influence of alcohol use on pancreatic cancer,pharyngeal carcinoma,upper gastrointestinal cancer and oral cancer was evaluated in one article respectively while 2 articles refer to the effect of alcohol use on colorectal cancer.There were 14 reports on the sample size of the population included,but none of the them reported the age of population.6 evaluated the methodological quality of the included study and described the quality assessment tools.Conclusion Combined multiple systematic reviews,excessive alcohol consumption may increase the risk of gastric cancer,pancreatic cancer and even increase the mortality of pancreatic cancer patients,and is significantly associated with the incidence of oral cancer and colorectal cancer.At present,the quality of systematic reviews for alcohol consumption and digestive system cancer is not good,the evidence level of conclusions are generally low,and the conclusions need to be verified by a large number of samples.Doctors should use the evidence carefully.
作者
佟雨珊
李雅萍
王梦艺
张帆
TONG Yushan;LI Yaping;WANG Mengyi;ZHANG Fan(Chongqing Medical University:Public Health and Management/Center for Medical and Social Development Research/Collaborative Innovation Center for Social Risk Prediction and Governance in the Field of Health,Chongqing 400016,China)
出处
《检验医学与临床》
CAS
2019年第S02期7-11,共5页
Laboratory Medicine and Clinic
基金
重庆市科学技术委员会基础科学与前沿技术研究项目(cstc2017jcyjAX0004)。
关键词
酒精
消化系统
癌症
系统评价
AMSTAR
alcohol
cancer of the digestive system
systematic review
Meta-analysis
overview
AMSTAR tools
