摘要
目的分析妊娠晚期高血压疾病孕妇的甲状腺功能状况,提高高危妊娠的管理。方法选400例妊娠晚期在我院住院分娩的孕妇为研究对象,分为妊娠期高血压组、子痫前期、慢性高血压组、对照组,各100例。检测研究对象的促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)及游离甲状腺素(FT4)进行甲状腺功能异常筛查。结果子痫前期组亚临床甲状腺功能减退(Subclinical hypothyroidism,简称亚甲减)发病率较对照组升高,FT4水平较对照组降低,差异均有统计学意义(P<0.05);慢性高血压组甲减/亚甲减及总甲状腺功能异常与对照组相比无差异(P>0.05);除年龄与TSH、FT 4无相关性外,其余各指标均呈现较弱的相关性,且差异有统计学意义(P<0.05)。结论妊娠晚期子痫前期患者亚甲减的发病率升高,游离甲状腺素水平降低;慢性高血压组甲状腺功能较对照组无明显变化。
Objective To analyze the thyroid function of late pregnant women with pregnancy induced hypertension and improve the management of high risk pregnancy.Methods A total of 400 pregnant women who were hospitalized in the late pregnancy in our hospital were selected as the research subjects.They were divided into hypertensive disorder complicating pregnancy,preeclampsia,chronic hypertension group and control group,100 cases in each group.Thyroid stimulating factor(TSH),free triiodothyronine(FT 3)and free thyroxine(FT 4)were screened for thyroid dysfunction.Results Preeclampsia group subclinical hypothyroidism(SCH)incidence was higher than the control group,the level of FT 4 was lower than the control group,respectively(P<0.05).The incidence of hypothyroidism/SCH and total thyroid dysfunction of chronic hypertension group compared with the control group,there was no obvious difference(P>0.05).Except age and TSH、age and FT 4,the other indexes showed a weak correlation,(P<0.05).Conclusion The incidence of SCH in patients with preeclampsia in the late pregnancy increased,free thyroxine level reduced;there was no significant change of the thyroid function in the chronic hypertension group compared with the control group.
作者
杨学敏
王兴和
王碧云
代炳梅
YANG Xuemin;WANG Xinghe;WANG Biyun;DAI Bingmei(Department of Obstetrics and Gynecology,Dongguan Maternal and Child Healthcare Hospital,Dongguan 523000,China)
出处
《广州医药》
2019年第6期69-72,共4页
Guangzhou Medical Journal
关键词
妊娠晚期
妊娠期高血压疾病
慢性高血压
子痫前期
甲状腺功能
Late trimester of pregnancy
Hypertensive disorder complicating pregnancy
Chronic hypertension
Preeclampsia
Thyroid function
