摘要
N^1,N^12-二乙酰精胺(N1,N12-diacetylspermine,DiAcSpm)是精胺的二乙酰化衍生物。精胺是真核细胞生长和蛋白质合成所必需的物质,而DiAcSpm更与癌症的发病情况有着密切的关系。现已发现多种癌症(非小细胞肺癌、结肠癌、乳腺癌等)患者尿液中的DiAcSpm水平均较正常人有不同程度的升高,表明DiAcSpm可能是一种优秀的广谱肿瘤标志物。对已发表的关于癌症患者体液中DiAcSpm水平变化情况的临床实验结果进行了分析,并对DiAcSpm与癌症的相关性予以综述。
N^1,N^12-diacetylspermine(DiAcSpm)is a diacetylated derivative of spermine.Spermine is required for eukaryotic cell growth and protein synthesis,and DiAcSpm is more closely related to the incidence of cancer.DiAcSpm levels in urine of various cancer patients(non-small cell lung cancer,colon cancer,breast cancer and so on)have been found to be significantly higher than those in normal subjects.This suggests that DiAcSpm may be a potential broad-spectrum tumor marker.The published clinical experiments on the changes of DiAcSpm content in body fluids of cancer patients are analyzed,and the correlation between DiAcSpm and cancer is reviewed.
作者
李锦
杨梦瑶
杨诚
孙涛
刘俊伟
LI Jin;YANG Mengyao;YANG Cheng;SUN Tao;LIU Junwei(Tianjin International Joint Academy of Biomedicine,Tianjin 300457,China;Tianjin International Joint Academy of Biomedicine Ltd.,Tianjin 300457,China;College of Pharmacy,Nankai University,Tianjin 300071,China)
出处
《天津科技》
2019年第12期85-88,共4页
Tianjin Science & Technology
基金
天津市科技计划项目“中药新药成药性综合评价技术研究”(18PTSYJC00060)
天津市“131”创新型人才培养第二层次人选培养项目
