摘要
目的:探讨伴有染色体核型异常的急性髓系白血病患者的疗效及预后。方法:收集并回顾性分析91例AML患者的临床特征、治疗反应,比较正常核型与异常核型患者的疗效与生存率。结果:染色体易位及单体核型为AML的主要异常核型。正常核型组与异常核型组在完全缓解率、总体治疗反应率上均无明显差异,异常核型组复发率增高。标准"3+7方案"与预激方案诱导化疗在正常核型组与异常核型组治疗反应上无明显差异。无复发存活时间(RFS)在正常核型组较异常核型组延长,OS时间无明显差异。结论:染色体核型异常是AML的独立预后因素,单体核型预后较差、复发率较高。
Objective:To investigate the efficacy and prognosis of acute myeloid leukemia(AML)patients with chromosome karyotype abnormalities.Methods:The clinical features and treatment responses of 91 patients with AML were collected and analyzed retrospectively.The efficacy and survival rate of the AML patients with normal and abnormal chromosome karyotype were compared.Results:Chromosome translocations and monosomal karyotypes were the main heterogeneity of AML.There was no significant difference in complete remission rate and overall response rate between the normal and abnormal karyotype groups,but the recurrence rate was higher in abnormal karyotype group.There was no significant difference in response of AML patients received the standard"3+7 regimen"and pre-excitation chemotherapy in the treatment of normal and abnormal karyotype groups.The relapse free survival time(RFS)was longer in the normal karyotype group,but there was no significant difference in overall survival time(O S).Conclusion:The abnormal karyotype of AML is an independent prognostic factor,monosomal karyotype shows a poor prognosis,and the recurrence rate in AML patients with monosomal karyotype is higher.
作者
陈月
陶善东
史玉叶
宋立孝
邓媛
凌兰兰
丁邦和
陈侃侃
何正梅
王春玲
于亮
CHEN Yue;TAO Shan-Dong;SHI Yu-Ye;SONG Li-Xiao;DENG Yuan;LING Lan-Lan;DING Bang-He;CHEN Kan-Kan;HE Zheng-Mei;WANG Chun-Ling;YU Liang(Department of Hematology,The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University,Huai'an 223300,Jiangsu Province,China;Key Laboratory of Hematology of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2019年第6期1717-1721,共5页
Journal of Experimental Hematology
基金
2017年度省第五期"333工程"科研资助立项项(BRA2017243)
2017年度淮安市第二期"533英才工程"科研资助立项项目(HAA201739)
淮安市科技局资助项目(HAB201810)
江苏省卫生健康委员会科研资助项目(H2018085)
南京医科大学附属淮安第一医院创新人才-青年人才项目
关键词
染色体核型异常
急性髓系白血病
疗效
预后因素
chromosome karyotype abnormalities
acute myeloid leukemia
efficacy
prognostic factors
