摘要
表观遗传学异常在血液系统肿瘤,特别在急性白血病(acute leukemia,AL)中起着重要作用。RNA甲基化是类似于DNA甲基化和组蛋白修饰的另一层表观遗传学改变,其中m6A甲基化是最广泛的RNA甲基化修饰方式,贯穿于RNA的生命周期的所有阶段,通过影响RNA代谢发挥生物学功能。多项研究表明,m6A甲基化在急性白血病的起病、发展、耐药等多方面有着关键调控作用。m6A甲基化的研究也将为AL的治疗提供新的思路。本文就m6A甲基化及其在AL发生,发展,治疗耐药中的作用的研究进展作一综述。
Objective:Epigenetic abnormalities play an important role in the pathogenesis of hematological malignancies,especially acute leukemia(AL).Similar to DNA methylation and histone modifications,RNA methylation is another important epigenetic modification.m6 A methylation is one of the most prevalent and extensively studied RNA methylation.m6 A methylation is involved in many biological and pathological process.Recent studies have found that m6 A methylation is involved in the occurrence,development and drug-resistance of AL.This review focuses on the research progress of m6 A methylation in AL.
作者
陈秋妮
陈月
纪婷婷
于亮
CHEN Qiu-Ni;CHEN Yue;JI Ting-Ting;YU Liang(Department of Hematology,The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University,Huai'an 223300,Jiangsu Province,China;Key Laboratory of Hematology of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2019年第6期2014-2018,共5页
Journal of Experimental Hematology
基金
2017年度江苏省第五期“333工程”科研资助立项项目(BRA2017243)
淮安市科技计划项目-新型临床诊疗技术攻关(HAS201608)
江苏省自然科学基金资助项目(BK20141254)
2017年度淮安市第二期“533英才工程”科研资助立项项目(HAA201739)
