摘要
目的:观察益智通脉颗粒联合盐酸多奈哌齐片治疗轻中度血管性痴呆(VD)患者的疗效及安全性。方法:将76例符合纳入条件的VD患者按照随机数字表法分为观察组和对照组各38例,两组均常规口服盐酸多奈哌齐片,观察组在此基础上加服益智通脉颗粒,疗程均为24周。治疗前及治疗12周末、24周末,分别观察两组主要疗效指标老年性痴呆评定量表-认知分量表(ADAS-cog)评分、中医证候积分,次要疗效指标简易精神状态量表(MMSE)得分、日常生活能力量表(ADL)评分;观察两组肝肾功能变化及有无恶心、胃脘不适等不良反应。结果:两组治疗后ADAS-cog评分、中医证候积分、MMSE评分、ADL评分均较治疗前有所改善(P<0.05),且用药时间越长,改善作用越明显,尤以观察组效果为著,组间比较差异有统计学意义(P<0.05);两组在治疗期间均未出现严重不良反应。结论:益智通脉颗粒联合盐酸多奈哌齐片可显著改善轻中度VD患者的认知功能及生活能力,且安全性高。
Objective:To investigate the efficacy and safety of Yizhi Tongmai Granules combining with Donepezil Tablets in treating mild to moderate vascular dementia(VD). Methods:Total 76 participants with VD meeting the including criteria were divided into two groups according to random number table,the observation group(38 cases) and the control group(38 cases). Both groups received Donepezil Tablets orally,while the observation group received Yizhi Tongmai Granules additionally,both for 24 weeks. Before treat ment and at the end of 12 weeks and 24 weeks after treatment,the main efficacy indicators of the two groups were observed such as:senile dementia rating scale-cognitive subscale(ADAS-cog) score,TCM syndrome score,and the secondary efficacy index such as:simple mental state scale(MMSE) score,daily life ability scale(ADL)score. Changes in liver and kidney functions and adverse reactions such as nausea and stomach discomfort were observed for both groups. Results:The ADAS-cog score,TCM syndrome score,MMSE score and ADL score of the two groups were improved compared with those before treatment. The longer the medication,the more obvious the improvement effect,especially in the observation group. There were statistically significant(P< 0.05) between groups;no serious adverse reactions occurred during the treatment period. Conclusions:Yizhi Tongmai Granules combined with Donepezil Tablets can significantly improve the cognitive function and living ability of patients with mild to moderate VD with high safety.
作者
刘媛
尹艳艳
司国民
LIU Yuan;YIN Yanyan;SI Guomin(Shandong Provincial Hospital Jinan 250021,China;Penglai Hospital of Traditional Chinese Medicine,Yantai 265600,China)
出处
《山东中医药大学学报》
2019年第6期564-567,共4页
Journal of Shandong University of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号：81473631)
关键词
益智通脉颗粒
血管性痴呆
肾精亏虚
痰浊阻窍证
瘀血阻络
认知功能
盐酸多奈哌齐片
Yizhi Tongmai Granules
vascular dementia
deficiency of kidney essence
turbid phlegm obstructing brain syndrome
blood stasis obstructing collaterals
cognitive function
Donepezil Tablets
