摘要
目的探讨阿普唑仑联合西酞普兰对糖尿病伴发抑郁症患者FPG、2 h PG、HbA1c水平的影响。方法选取2016年5月至2018年7月本院收治的糖尿病伴发抑郁症患者113例作为研究对象,采用随机数表法将其分为试验组(56例)和对照组(57例)。所有患者均行常规对症处理,对照组给予单纯西酞普兰治疗,试验组采用阿普唑仑联合西酞普兰治疗。比较两组治疗效果。结果治疗后,两组患者HAMA、HAMD评分均明显降低,且试验组低于对照组(P<0.05)。治疗后,试验组FPG、2 h PG和HbA1c水平均明显低于对照组(P<0.05)。试验组药物不良反应总发生率明显低于对照组(P<0.05)。结论阿普唑仑联合西酞普兰治疗糖尿病伴发抑郁症能快速改善患者情绪状态,提高血糖控制效果,药物不良反应少,安全性高,值得临床推广应用。
Objective To investigate the effects of alprazolam combined with citalopram on the levels of FPG, 2 h PG and HbA1 c in diabetes patients with depression. Methods A total of 113 diabetes patients with depression admitted in our hospital from May 2016 to July 2018 were selected as the study objects. The patients were divided into experimental group(56 cases) and control group(57 cases) by random number table method. All patients underwent routine symptomatic treatment, and the control group was treated with citalopram alone, the experimental group was treated with alprazolam combined with citalopram. The therapeutic effects of the two groups were compared. Results After treatment, the scores of HAMA and HAMD of the two groups reduced significantly, and those of the experimental group were lower than the control group(P<0.05). After treatment, the levels of FPG, 2 h PG and HbA1 c in the experimental group were significantly lower than those in the control group(P <0.05). The total incidence of drug adverse reactions in the experimental group was significantly lower than that in the control group(P <0.05). Conclusion Alprazolam combined with citalopram in the treatment of diabetes with depression can rapidly improve the patients’ emotional state and blood sugar control effect, with fewer adverse drug reactions and high safety, which is worthy of clinical popularization and application.
作者
陈红
王丹
CHEN Hong;WANG Dan(the First People's Hospital of Xianyang,Xianyang 712000;Xi'an International Medical Center Hospital,Xi'an 710075,China)
出处
《临床医学研究与实践》
2019年第36期45-47,共3页
Clinical Research and Practice
关键词
阿普唑仑
西酞普兰
空腹血糖
餐后血糖
糖化血红蛋白
alprazolam
citalopram
fasting blood glucose
postprandial blood glucose
glycated hemoglobin
