摘要
目的探讨肿瘤标志物CA153、CA125在肺癌临床诊断中的应用价值及诊断效能。方法选择2017年1月至2019年3月我院疑似肺癌患者64例作为肺癌组、同期治疗的良性肺肿瘤患者64例作为良性肿瘤组、同期健康体检者64例作为健康组。三组研究对象均采用化学发光分析法完成CA153、CA125水平测定。比较三组研究对象的血清CA153、CA125水平、不同病理特点的肺癌组患者的CA153、CA125水平及血清肿瘤标志物CA153、CA125检测及联合检测在肺癌组患者中的诊断效能。结果肺癌组与良性肿瘤组的CA153和CA125水平均高于健康组,肺癌组的CA153和CA125水平均高于良性肿瘤组(P <0.05)。不同肿瘤直径、淋巴结转移、TNM分期、分化类型肺癌组患者的CA153、CA125水平比较,差异具有统计学意义(P<0.05)。以手术组织检查作为金标准,血清肿瘤标志物CA153、CA125联合检测在肺癌组患者诊断中的灵敏度和特异度均高于CA153、CA125单独检测(P<0.05)。结论肿瘤标志物CA153和CA125联合应用于肿瘤检测中能够显著提高肺癌的诊断效果,且其表达水平能反映患者的疾病严重程度,有助于肺癌的早期诊断和治疗,值得推广应用。
Objective To investigate the application value and diagnostic efficacy of tumor markers CA153 and CA125 in the clinical diagnosis of lung cancer. Methods From January 2017 to March 2019, 64 patients with suspected lung cancer in our hospital were selected as lung cancer group, 64 patients with benign lung tumor treated at the same period were selected as benign tumor group, and 64 health person who underwent physical examination at the same period were selected as healthy group. The levels of CA153 and CA125 in the three groups were detected by chemiluminescence analysis method.The serum CA153 and CA125 levels of the three groups, CA153 and CA125 levels of the lung cancer group with different pathological characteristics and diagnostic efficacy of the detection of serum tumor markers CA153, CA125 and combined detection in the lung cancer group were compared. Results The levels of CA153 and CA125 in the lung cancer group and the benign tumor group were higher than those in the healthy group, and the levels of CA153 and CA125 in the lung cancer group were higher than those in the benign tumor group(P<0.05). There were statistically significant in expressions of CA153 and CA125 of patients in different tumor diameters, lymph node metastasis, TNM staging and differentiation types of the lung cancer group(P<0.05). Surgical tissue examination was set as the gold standard, and the sensitivity and specificity of the combined detection of serum tumor markers CA153 and CA125 in the lung cancer group were higher than those of CA153 or CA125 alone detection(P <0.05). Conclusion The combined detection of serum tumor markers CA153 and CA125 can significantly improve the diagnostic effect of lung cancer, and the expression levels of which can reflect the severity of the disease. It is helpful for the early diagnosis and treatment of lung cancer, which is worthy of popularization and application.
作者
康联宗
肖金玉
王晓旭
KANG Lian-zong;XIAO Jin-yu;WANG Xiao-xu(Ankang People's Hospital,Ankang 725000,China)
出处
《临床医学研究与实践》
2019年第36期127-129,共3页
Clinical Research and Practice
