摘要
目的探讨止颤汤联合西药治疗帕金森病的临床效果及对患者震颤症状和生活质量的影响。方法选取我院2017年6月至2018年12月收治的78例帕金森病患者作为研究对象,采用奇偶分组法将其分为研究组(39例,止颤汤+单唾液酸四己糖神经节苷脂钠+脑蛋白水解物)和参照组(39例,单唾液酸四己糖神经节苷脂钠+脑蛋白水解物)。比较两组的临床疗效、统一帕金森病评定量表(UPDRS)评分及不良反应(胃肠不适、皮疹、恶心)发生情况。结果研究组的治疗总有效率为92.31%,明显高于参照组的69.23%,差异具有统计学意义(P<0.05)。治疗前,两组患者的运动功能、精神和情感行为、日常生活能力、治疗并发症评分及UPDRS总分比较,差异无统计学意义(P>0.05);治疗12周后,两组患者运动功能、精神和情感行为、日常生活能力、治疗并发症评分及UPDRS总分均降低,且研究组均明显低于参照组,差异具有统计学意义(P<0.05)。研究组患者的不良反应总发生率为5.13%,明显低于参照组的20.51%,差异具有统计学意义(P<0.05)。结论止颤汤联合西药治疗帕金森病的临床效果显著,可改善患者的临床症状,减少不良反应发生率,进而提升患者的生活质量,值得临床推广应用。
Objective To explore the clinical effect of Zhichan decoction combined with western medicine on Parkinson’s disease and its influence on tremor symptoms and quality of life of patients. Methods A total of 78 patients with Parkinson’s disease admitted in our hospital from June 2017 to December 2018 were selected as the research objects and divided into study group(39 cases, Zhichan decoction +monosialotetrahexosylganglioside sodium +cerebroprotein hydrolysate) and reference group(39 cases, monosialotetrahexosylganglioside sodium+cerebroprotein hydrolysate) according to the even and odd grouping method. The clinical efficacy, unified Parkinson’s disease rating scale(UPDRS) score and adverse reactions(gastrointestinal discomfort, rash, nausea) of the two groups were compared. Results The total effective rate of treatment in the study group was 92.31%, which was significantly higher than 69.23% in the reference group, and the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in the scores of motor function, mental and emotional behavior, ability of daily life, treatment complications and UPDRS total score between the two groups(P>0.05);after 12 weeks of treatment, the scores of motor function, mental and emotional behavior, ability of daily life, treatment complications and UPDRS total score of the two groups decreased, and those in the study group were significantly lower than the reference group, and the differences statistically significant(P <0.05). The total incidence of adverse reactions in the study group was 5.13%, which was significantly lower than 20.51% in the reference group, and the difference was statistically significant(P<0.05). Conclusion Zhichan decoction combined with western medicine on patients with Parkinson’s disease has a significant clinical effect, it can improve the clinical symptoms of patients, reduce the incidence of adverse reactions, and improve the quality of life of patients, which is worthy of clinical promotion and application.
作者
张艳
罗思宁
张欢
武兴兴
ZHANG Yan;LUO Si-ning;ZHANG Huan;WU Xing-xing(Xianyang Central Hospital,Xianyang 712000,China)
出处
《临床医学研究与实践》
2019年第36期146-148,共3页
Clinical Research and Practice
关键词
帕金森病
止颤汤
单唾液酸四己糖神经节苷脂钠
脑蛋白水解物
统一帕金森病评定量表
Parkinson's disease
Zhichan decoction
monosialotetrahexosylganglioside sodium
cerebroprotein hydrolysate
unified Parkinson's disease rating scale
