摘要
JAK-STAT通路是一个经典的细胞信号转导通路,对正常细胞的增殖、迁移、分化,以及细胞周期等有重要的调节介导作用,同时JAK通路的激活还与肿瘤细胞的发生、生长、凋亡抑制和转移密切相关。三阴性乳腺癌是一种恶性肿瘤,目前在亚洲女性身上发病率持续升高,也是致死率较高的肿瘤类型。在针对三阴性乳腺癌的治疗当中除传统的手术治疗与术后化疗,免疫治疗的发展也为乳腺癌的治疗提供一种新的思路。研究表明,JAK-STAT通路与体内免疫细胞激活有着密切的联系,可望成为全身的免疫药物的新靶点。本文总结了JAK-STAT通路与免疫趋化因子之间的关系,并就其在乳腺癌治疗中的潜在应用进行了初步的探讨。
JAK-STAT is a classic signaling pathway which plays important regulatory roles in cell cycle,cell proliferation,migration,and differentiation.The activation of JAK pathway is also closely related to the growth,apoptosis or metastasis of several types of tumor cells,including breast cancer.Tri-negative breast cancer is a type of malignant tumor with high mortality.Currently,the rate of TNBC is continuously high in Asian women.Except the traditional surgical treatment and chemotherapy,the development of immunotherapy also provides a new idea for the treatment of breast cancer.Several researches have shown that the JAK-STAT pathway is closely related to the activation of immune cells in vivo and it may become a new drug target for tumor immunotherapy.
作者
金振硕
王海燕
JIN Zhen-Shuo;WANG Hai-Yan(Tsinghua University School of Medicine,Beijing 100084,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2019年第23期2942-2944,F0003,共4页
Chinese Journal of Immunology
