摘要
目的探讨鼻咽癌患者治疗前外周血淋巴细胞与中性粒细胞比值(LNR)和淋巴细胞与单核细胞比值(LMR)等指标评估鼻咽癌患者预后的价值.方法回顾性分析2015年12月~2017年10月在安徽省肿瘤医院行鼻咽癌放、化疗治疗的160例鼻咽癌患者的血常规结果,纳入本组研究的临床分期为Ⅰ期6例、Ⅱ期21例、Ⅲ期62例、Ⅳ期71例,采用Sysmex–XE 5000血细胞分析仪检测患者外周血白细胞计数(WBC)、中性粒细胞计数(N)、淋巴细胞计数(L)、单核细胞计数(M)等指标,计算淋巴细胞与中性粒细胞比值(LNR)、淋巴细胞与单核细胞比值(LMR).结果鼻咽癌患者与健康体检对照组比较,白细胞计数(WBC)、中性粒细胞百分率(NEUTR%)、淋巴细胞百分率(LYR%)、LNR的差异无统计学意义(P>0.05);鼻咽癌病情稳定患者治疗前LNR、LMR值明显低于发现远处转移及复发鼻咽癌患者(P<0.05).结论定期测定鼻咽癌患者治疗前外周血LNR、LMR可以作为评价鼻咽癌患者无进展生存预后的有用指标.
Objective To investigate the therapeutic effect and correlation analysis of peripheral lymphocyte and neutrophil ratio(LNR)and ratio of lymphocytes to monocytes in patients with nasopharyngeal carcinoma before treatment.Methods We retrospectively analyzed the blood routine results of 160 cases of nasopharyngeal carcinoma treated by radiotherapy and chemotherapy of nasopharyngeal carcinoma in Cancer Hospital of Anhui Province from December 2015 to October 2017.The clinical stage included in this study was stageⅠin 6 cases,21 cases of stageⅡ,62 cases of stageⅢand 71 cases of stageⅣ.The levels of WBC,NEUT%and LY%of peripheral blood were detected by Sysmex-XE 5000 hematology analyzer,Monocyte percentage(MONO%)and other indicators,calculate the lymphocyte to neutrophil ratio(LNR),lymphocyte to monocyte ratio(LMR).Results There were no significant differences in WBC,NEUTR%,LYR%and LNR between NPC patients and controls(P>0.05).LNR and LMR of patients with stable nasopharyngeal carcinoma(P<0.05).Conclusions The determination of peripheral blood lymphocyte to neutrophil ratio,lymphocyte to monocyte ratio before treatment in patients with nasopharyngeal carcinoma can be used as evaluation index Pharyngeal cancer patients with progression-free survival and prognosis of useful indicators.
作者
常人亮
王蓓
胡良俊
万玲玲
李明
CHANG Ren-liang;WANG Bei;HU Liang-jun(Department of clinical laboratory,Anhui Province Cancer Hospitai,Hefei 230031)
出处
《临床输血与检验》
CAS
2019年第6期630-632,共3页
Journal of Clinical Transfusion and Laboratory Medicine
基金
安徽省自然科学基金(No.1308085QH144)资助
